Evidence map›Paper›PMID 29382730›Full record

ArticlemBio2018

Translation Stress Positively Regulates MscL-Dependent Excretion of Cytoplasmic Proteins.

Rosa Morra, Francesco Del Carratore, Howbeer Muhamadali, Luminita Gabriela Horga, Samantha Halliwell, Royston Goodacre, Rainer Breitling, Neil Dixon

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Life science alliance · 2023
    Article
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  5. Article
  6. Article
  7. Review
  8. The Rocky Road From Fed-Batch to Continuous Processing WithFrontiers in bioengineering and biotechnology · 2019
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rosa MorraManchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester, United Kingdom.
Francesco Del CarratoreManchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester, United Kingdom.
Howbeer MuhamadaliManchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester, United Kingdom.
Luminita Gabriela HorgaManchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester, United Kingdom.
Samantha HalliwellManchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester, United Kingdom.
Royston GoodacreManchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester, United Kingdom.ORCID 0000-0003-2230-645X
Rainer BreitlingManchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester, United Kingdom.ORCID 0000-0001-7173-0922
Neil DixonManchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester, United Kingdom neil.dixon@manchester.ac.uk.ORCID 0000-0001-9065-6764
University of Manchester · GB

Funding

Biotechnology and Biological Sciences Research Council BB/K014773/1Biotechnology and Biological Sciences Research Council BB/L013649/1Biotechnology and Biological Sciences Research Council BB/M017702/1
6 · The paper itself

Abstract

The apparent mislocalization or excretion of cytoplasmic proteins is a commonly observed phenomenon in both bacteria and eukaryotes. However, reports on the mechanistic basis and the cellular function of this so-called "nonclassical protein secretion" are limited. Here we report that protein overexpression in recombinant cells and antibiotic-induced translation stress in wild-type

Indexed as

Anti-Bacterial AgentsEscherichia coliEscherichia coli ProteinsGene Knockout TechniquesIon ChannelsMetabolomeOsmotic PressureProtein BiosynthesisProtein TransportProteomeRNA-Binding ProteinsAnti-Bacterial AgentsArfA protein, E coliEscherichia coli ProteinsIon ChannelsMscL protein, E coliProteomeRNA-Binding ProteinsArfAMscLosmotic stressprotein excretiontranslation stress

Identifiers

PMID29382730
PMCPMC5790912
OpenAlexW2781534846

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.