Evidence map›Paper›PMID 29382721›Full record

ArticleThe Journal of biological chemistry2018

Both positional and chemical variables control

Swe-Htet Naing, Sibel Kalyoncu, David M Smalley, Hyojung Kim, Xingjian Tao, Josh B George, Alex P Jonke, Ryan C Oliver, Volker S Urban, Matthew P Torres and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  8. Taking a position on intramembrane proteolysis.The Journal of biological chemistry · 2018
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Swe-Htet NaingSchool of Chemistry and Biochemistry, Atlanta, Georgia 30332.
Sibel KalyoncuSchool of Chemistry and Biochemistry, Atlanta, Georgia 30332.
David M SmalleyPetit Institute for Bioengineering and Biosciences, Atlanta, Georgia 30332.
Hyojung KimSchool of Chemistry and Biochemistry, Atlanta, Georgia 30332; School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332.
Xingjian TaoSchool of Chemistry and Biochemistry, Atlanta, Georgia 30332.
Josh B GeorgeSchool of Chemistry and Biochemistry, Atlanta, Georgia 30332.
Alex P JonkeSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332.
Ryan C OliverNeutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831.
Volker S UrbanNeutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831.
Matthew P TorresSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332.
Raquel L LiebermanSchool of Chemistry and Biochemistry, Atlanta, Georgia 30332. Electronic address: raquel.lieberman@chemistry.gatech.edu.
University of Atlanta · USGeorgia Institute of Technology · USOak Ridge National Laboratory · US

Funding

DRILL: Droplet Desolvation and Ion Transmission Interface for Mass SpectrometryR01GM112662 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI FEDOROV, ANDREI G, MUDDIMAN, DAVID C. · 2014 to 2017
$2.2M
The Role of Cu/Zn Superoxide Dismutase (SOD1) in Redox SignalingR01GM118744 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI REDDI, AMIT RAM · 2016 to 2020
$1.6M
NIGMS NIH HHS R01 GM112662NIGMS NIH HHS R01 GM118744
6 · The paper itself

Abstract

Mechanistic details of intramembrane aspartyl protease (IAP) chemistry, which is central to many biological and pathogenic processes, remain largely obscure. Here, we investigated the

Indexed as

Archaeal ProteinsAspartic Acid ProteasesMethanomicrobiaceaePresenilinsProteolysisArchaeal ProteinsAspartic Acid ProteasesPresenilinsAlzheimer diseaseamyloid precursor protein (APP)enzyme kineticsintramembrane proteolysismass spectrometry (MS)membrane enzymeneurodegenerative diseasepresenilinsubstrate specificity

Identifiers

PMID29382721
PMCPMC5880133
OpenAlexW2786421526

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.