ArticleBMJ open2018
Fatty liver index, albuminuria and the association with chronic kidney disease: a population-based study in China.
Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Fatty liver index (FLI): more than a marker of hepatic steatosis.Journal of physiology and biochemistry · 2024Pooled it
- Association of cholesterol, high-density lipoprotein, and glucose (CHG) index with chronic kidney disease in Chinese community adults: findings from the REACTION study.Frontiers in nutrition · 2026Article
- Article
- Proteinuria and risk of ocular motor cranial nerve palsy: a nationwide population-based study.Scientific reports · 2024Article
- Fatty Liver Index (FLI) Identifies Not Only Individuals with Liver Steatosis but Also at High Cardiometabolic Risk.International journal of molecular sciences · 2023Article
- Fatty Liver Index and Its Association with 10-Year Atherosclerotic Cardiovascular Disease Risk: Insights from a Population-Based Cross-Sectional Study in China.Metabolites · 2023Article
- The Fatty Liver Index, the Strongest Risk Factor for Low Testosterone Level.Obesity facts · 2023Article
- Serum uric acid is related to liver and kidney disease and 12-year mortality risk after myocardial infarction.Frontiers in endocrinology · 2023Article
- Effects of Boric Acid and Storage Temperature on the Analysis of Microalbumin Using Aptasensor-Based Fluorescent Detection.Biosensors · 2022Article
- Circulating PCSK7 Level is Independently Associated with Obesity, Triglycerides Level and Fatty Liver Index in a General Population without Medication.Journal of atherosclerosis and thrombosis · 2022Article
- Association of serum creatinine with hepatic steatosis and fibrosis: a cross-sectional study.BMC gastroenterology · 2022Article
- Fatty liver index is independently associated with deterioration of renal function during a 10-year period in healthy subjects.Scientific reports · 2021Article
- Proteinuria Is Associated with the Development of Crohn's Disease: A Nationwide Population-Based Study.Journal of clinical medicine · 2021Article
- RETRACTED: Lipolytic Postbiotic fromMolecules (Basel, Switzerland) · 2021Article
- The association between NAFLD and risk of chronic kidney disease: a cross-sectional study.Therapeutic advances in chronic disease · 2021Article
- Impact of Fasting Lipid Profile on Chronic Kidney Disease Patients Having Fatty Liver Disease.Cureus · 2020Article
- Elevated triglycerides rather than other lipid parameters are associated with increased urinary albumin to creatinine ratio in the general population of China: a report from the REACTION study.Cardiovascular diabetology · 2019Observational
- Association of fatty liver disease with mortality outcomes in an Eastern Finland male cohort.BMJ open gastroenterology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe effects of lipid metabolism disorder on renal damage have drawn much attention. Using the fatty liver index (FLI) as a validated indicator of hepatic steatosis, this study aims to provide insight about the possible links between fatty liver and the development of chronic kidney disease (CKD).
settingHospital.
participantsWe performed a population-based study on 9436 subjects aged 40 years or older. PRIMARY AND SECONDARY OUTCOME MEASURES: FLI is calculated using an algorithm based on body mass index, waist circumference, triglycerides and γ-glutamyltransferase. Increased urinary albumin excretion was defined according to the urinary albumin to creatinine ratio ranges ≥30 mg/g. CKD was defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m² or presence of albuminuria.
resultsThere were 620 (6.6%) subjects categorised to have increased urinary albumin excretion and 753 (8.0%) subjects categorised to have CKD. Participants with higher FLI had increased age, blood pressure, low-density lipoprotein cholesterol, fasting plasma glucose, fasting insulin and decreased eGFR level. Prevalence of increased urinary albumin excretion and CKD tended to increase with the elevated FLI quartiles. In logistic regression analysis, compared with subjects in the lowest quartile of FLI, the adjusted ORs in the highest quartile were 2.30 (95% CI 1.36 to 3.90) for increased urinary albumin excretion and 1.93 (95% CI 1.18 to 3.15) for CKD.
conclusionHepatic steatosis evaluated by FLI is independently associated with increased urinary albumin excretion and prevalence of CKD in middle-aged and elderly Chinese.
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