Evidence map›Paper›PMID 29382379›Full record

Observational studyArthritis research & therapy2018

Can baseline ultrasound results help to predict failure to achieve DAS28 remission after 1 year of tight control treatment in early RA patients?

D F Ten Cate, J W G Jacobs, W A A Swen, J M W Hazes, M H de Jager, N M Basoski, C J Haagsma, J J Luime, A H Gerards

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Arthritis research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01752309 (The Predictive Value of Ultrasound in Early Rheumatoid Arthritis), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01752309 completednot on this map

The Predictive Value of Ultrasound in Early Rheumatoid Arthritis

TypeobservationalSponsorErasmus Medical CenterRan2010 to 2013Enrolled150ConditionsRheumatoid Arthritis, Predictive Value of Ultrasound in Early Rheumatoid Arthritis
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

D F Ten CateDepartment of Rheumatology, Erasmus University Medical Center, Room Na-609; 0031-10-7038251, PO Box 2040, 3000, CA, Rotterdam, The Netherlands. d.tencate@erasmusmc.nl.
J W G JacobsDepartment of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
W A A SwenRheumatology, Medical Center Alkmaar, Alkmaar, The Netherlands.
J M W HazesDepartment of Rheumatology, Erasmus University Medical Center, Room Na-609; 0031-10-7038251, PO Box 2040, 3000, CA, Rotterdam, The Netherlands.
M H de JagerRheumatology, Albert Schweitzer Hospital, Dordrecht, The Netherlands.
N M BasoskiRheumatology, Maasstad Hospital, Rotterdam, The Netherlands.
C J HaagsmaRheumatology, Hospital Group Twente, Almelo, The Netherlands.
J J LuimeDepartment of Rheumatology, Erasmus University Medical Center, Room Na-609; 0031-10-7038251, PO Box 2040, 3000, CA, Rotterdam, The Netherlands.
A H GerardsRheumatology, Vlietland Hospital Schiedam, Schiedam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAt present, there are no prognostic parameters unequivocally predicting treatment failure in early rheumatoid arthritis (RA) patients. We investigated whether baseline ultrasonography (US) findings of joints, when added to baseline clinical, laboratory, and radiographical data, could improve prediction of failure to achieve Disease Activity Score assessing 28 joints (DAS28) remission (<2.6) at 1 year in newly diagnosed RA patients.

methodsA multicentre cohort of newly diagnosed RA patients was followed prospectively for 1 year. US of the hands, wrists, and feet was performed at baseline. Clinical, laboratory, and radiographical parameters were recorded. Primary analysis was the prediction by logistic regression of the absence of DAS28 remission 12 months after diagnosis and start of therapy.

resultsOf 194 patients included, 174 were used for the analysis, with complete data available for 159. In a multivariate model with baseline DAS28 (odds ratio (OR) 1.6, 95% confidence interval (CI) 1.2-2.2), the presence of rheumatoid factor (OR 2.3, 95% CI 1.1-5.1), and type of monitoring strategy (OR 0.2, 95% CI 0.05-0.85), the addition of baseline US results for joints (OR 0.96, 95% CI 0.89-1.04) did not significantly improve the prediction of failure to achieve DAS28 remission (likelihood ratio test, 1.04; p = 0.31).

conclusionIn an early RA population, adding baseline ultrasonography of the hands, wrists, and feet to commonly available baseline characteristics did not improve prediction of failure to achieve DAS28 remission at 12 months.

trial registrationClinicaltrials.gov, NCT01752309 . Registered on 19 December 2012.

Indexed as

Severity of Illness IndexAdultAgedAntirheumatic AgentsArthritis, RheumatoidCohort StudiesFemaleHandHumansMaleMethotrexateMiddle AgedPrognosisTreatment OutcomeUltrasonographyWristAntirheumatic AgentsMethotrexateArthritisLogistic modelsPredictionPrognosisRemissionRheumatoidUltrasonography

Identifiers

PMID29382379
PMCPMC5791342

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.