Evidence map›Paper›PMID 29382349›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2018

Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study.

Jonathan R Weir-McCall, Matthew Lambert, Stephen J Gandy, Jill J F Belch, Ian Cavin, Shelley A Henderson, Roberta Littleford, Jennifer A Macfarlane, Shona Z Matthew, R Stephen Nicholas and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Sodium-Glucose Cotransporter 2 Inhibitors and Cardiac Remodeling.Journal of cardiovascular translational research · 2022
    Review
  2. Endothelial progenitor/stem cells in engineered vessels for vascular transplantation.Journal of materials science. Materials in medicine · 2020
    Article
  3. Journal of Cardiovascular Magnetic Resonance: 2017/2018 in review.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Jonathan R Weir-McCallDivision of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Dundee, DD1 9SY, UK.
Matthew LambertDivision of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Dundee, DD1 9SY, UK.
Stephen J GandyNHS Tayside Medical Physics, Ninewells Hospital, Dundee, UK.
Jill J F BelchDivision of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Dundee, DD1 9SY, UK.
Ian CavinNHS Tayside Medical Physics, Ninewells Hospital, Dundee, UK.
Shelley A HendersonNHS Tayside Medical Physics, Ninewells Hospital, Dundee, UK.
Roberta LittlefordDivision of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Dundee, DD1 9SY, UK.
Jennifer A MacfarlaneNHS Tayside Medical Physics, Ninewells Hospital, Dundee, UK.
Shona Z MatthewDivision of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Dundee, DD1 9SY, UK.
R Stephen NicholasNHS Tayside Medical Physics, Ninewells Hospital, Dundee, UK.
Allan D StruthersDivision of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Dundee, DD1 9SY, UK.
Frank SullivanDepartment of Research and Innovation, North York General Hospital, University of Toronto, Toronto, Canada.
Richard D WhiteDepartment of Clinical Radiology, University Hospital of Wales, Cardiff, CF14 4XW, UK.
J Graeme HoustonDivision of Molecular and Clinical Medicine, College of Medicine, University of Dundee, Level 7, Dundee, DD1 9SY, UK. j.g.houston@dundee.ac.uk.
University of Dundee · GBNinewells Hospital · GBNHS Tayside · GBNorth York General Hospital · CAUniversity Hospital of Wales · GB

Funding

Wellcome TrustWellcome Trust WT085664
6 · The paper itself

Abstract

backgroundArteriosclerosis (arterial stiffening) is associated with future cardiovascular events, with this effect postulated to be due to its effect on cardiac afterload, atherosclerosis (plaque formation) progression or both, but with limited evidence examining these early in disease formation. The aim of the current study is to examine the association between arteriosclerosis, atherosclerosis and ventricular remodelling in a population at low-intermediate cardiovascular risk.

methodsOne thousand six hundred fifty-one subjects free of clinical cardiovascular disease and with a < 20% 10 year cardiovascular risk score underwent a cardiovascular magnetic resonance (CMR) study and whole body CMR angiogram. Arteriosclerosis was measured using total arterial compliance (TAC) - calculated as the indexed stroke volume divided by the pulse pressure. Atherosclerosis was quantified using a standardised atheroma score (SAS) which was calculated by scoring 30 arterial segments within the body based on the degree of stenosis, summating these scores and normalising it to the number of assessable segments. Left ventricular remodelling was measured using left ventricular mass to volume ratio (LVMVR).

resultsOne thousand five hundred fifteen (38% male, 53.8 ± 8.2 years old) completed the study. On univariate analysis TAC was associated with SAS but this was lost after accounting for cardiovascular risk factors in both males (B = - 0.001 (- 0.004-0.002),p = 0.62) and females (B = 0.000(95%CI -0.002--0.002),p = 0.78). In contrast compliance correlated with LVMVR after accounting for cardiovascular risk factors (B = - 0.12(95%CI -0.16--0.091),p < 0.001 in males; B = - 0.12(95%CI -0.15--0.086),p < 0.001 in females).

conclusionSystemic arteriosclerosis is associated with left ventricular remodelling but not atherosclerosis. Future efforts in cardiovascular risk prevention should thus seek to address both arteriosclerosis and atherosclerosis individually.

Indexed as

Magnetic Resonance AngiographyMagnetic Resonance Imaging, CineVascular StiffnessVentricular Function, LeftVentricular RemodelingArteriosclerosisCase-Control StudiesFemaleHeart DiseasesHumansMaleMiddle AgedPeripheral Arterial DiseasePlaque, AtheroscleroticPredictive Value of TestsPrognosisArterial complainceArteriosclerosisAtherosclerosisCardiovascular riskLeft ventricle

Identifiers

PMID29382349
PMCPMC5791244
OpenAlexW2789385040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.