ArticleBMC pediatrics2018
C-reactive protein for late-onset sepsis diagnosis in very low birth weight infants.
Article in BMC pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Utility of volatile organic compounds as a diagnostic tool in preterm infants.Pediatric research · 2021Pooled it
- Assessment of C-Reactive Protein Diagnostic Test Accuracy for Late-Onset Infection in Newborn Infants: A Systematic Review and Meta-analysis.JAMA pediatrics · 2020Pooled it
- Association Between Maternal C-Reactive Protein (CRP) Levels and Adverse Neonatal Outcomes: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Diagnostic biomarkers for late-onset sepsis in pediatric intensive care: a retrospective cohort study.BMC pediatrics · 2025Article
- Theoretical impact of a bedside decision-making tool on antibiotic use for suspected neonatal healthcare-associated infection: an observational study.BMC pediatrics · 2025Observational
- A study protocol for neonatal sepsis and gut microbiomics among preterm infants admitted at Muhimbili National Hospital, Tanzania.PloS one · 2025Article
- Biomarkers of Neonatal Sepsis: Where We Are and Where We Are Going.Antibiotics (Basel, Switzerland) · 2023Review
- The Role of Coagulase-Negative Staphylococci Biofilms on Late-Onset Sepsis: Current Challenges and Emerging Diagnostics and Therapies.Antibiotics (Basel, Switzerland) · 2023Review
- Procalcitonin is a prognosis biomarker in very preterm neonates with late onset sepsis: a pilot study.European journal of pediatrics · 2022Observational
- Assessment of a score's performance in predicting positive culture studies in preterm neonates with clinical suspicion of sepsis.Journal of mother and child · 2022Article
- Prediction modelling in the early detection of neonatal sepsis.World journal of pediatrics : WJP · 2022Review
- Clinical and Laboratory Findings of Nosocomial Sepsis in Extremely Low Birth Weight Infants According to Causative Organisms.Journal of clinical medicine · 2022Article
- Article
- Review
- Antibiotic Discontinuation 24 h After Neonatal Late-Onset Sepsis Work-Up-A Validated Decision Tree Model.Frontiers in pediatrics · 2021Article
- Can we improve early identification of neonatal late-onset sepsis? A validated prediction model.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Procalcitonin versus C-reactive protein: review of kinetics and performance for diagnosis of neonatal sepsis.Journal of perinatology : official journal of the California Perinatal Association · 2019Review
- Dependence of the severity of the systemic inflammatory response on resistance to hypoxia in male Wistar rats.Journal of inflammation research · 2019Article
- Morphological Characteristics of the Thymus and Spleen and the Subpopulation Composition of Lymphocytes in Peripheral Blood during Systemic Inflammatory Response in Male Rats with Different Resistance to Hypoxia.International journal of inflammation · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLate-onset sepsis in very low birth weight (VLBW) infants is a diagnostic challenge. We aimed to evaluate the diagnostic utility of the C-Reactive protein (CRP) and the complete blood count (CBC) for late-onset sepsis in VLBW infants.
methodsIn a 5-year retrospective cohort of 416 VLBW infants born at less than 1500 g, there were 590 separate late-onset sepsis evaluations. CRP and CBC were drawn at time of initial blood culture (T0), at 16-24 h (T24) and 40-48 h (T48) after. The positive cut-off values for abnormal values were the following: CRP ≥10 mg/L and CBC with at least one anomaly, including white blood cell count < 5000/mm
resultsAt T0, combining the CBC and the CRP had the highest sensitivity of 66% (95% confidence interval [CI], 58-73) compared to both individual tests for predicting late onset sepsis. At T24, CRP's sensitivity was 84% (95% CI, 78-89) and was statistically higher than the CBC's 59% (95% CI, 51-67). The combination of CBC at T0 and CRP at T24 offered the greatest sensitivity of 88% (95% CI, 82-92) and negative predictive value 93% (95% CI, 89-96), with fewer samples, compared to any other combination of tests. The area under the curve for the change in the white blood cell count from T0 to T24 was 0.82.
conclusionAt initial sepsis evaluation (T0), both CBC and CRP should be performed to increase sensitivity. A highly negative predictive value is reachable with only two tests: a CBC at T0 and a CRP a T24.
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