Evidence map›Paper›PMID 29382166›Full record

ArticleToxins2018

Activation of Aflatoxin Biosynthesis Alleviates Total ROS in Aspergillus parasiticus.

Gabriel J Kenne, Phani M Gummadidala, Mayomi H Omebeyinje, Ananda M Mondal, Dominic K Bett, Sandra McFadden, Sydney Bromfield, Nora Banaszek, Michelle Velez-Martinez, Chandrani Mitra and 4 more

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
7.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 44 citations in OpenAlex.

  1. Ectopic Expression ofCurrent issues in molecular biology · 2026
    Article
  2. Characterization ofJournal of fungi (Basel, Switzerland) · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Molecular regulation of fungal secondary metabolism.World journal of microbiology & biotechnology · 2023
    Review
  8. Frontiers in microbiology · 2023
    Article
  9. Review
  10. Genome Analysis of the Broad Host Range NecrotrophFrontiers in plant science · 2022
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Exposure ofFrontiers in microbiology · 2019
    Article
  17. Article
  18. Enhancement of Pneumocandin BFrontiers in microbiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Gabriel J KenneDepartment of Environmental Health Sciences, University of South Carolina, Columbia, SC 29208, USA. gkenne@email.sc.edu.
Phani M GummadidalaDepartment of Environmental Health Sciences, University of South Carolina, Columbia, SC 29208, USA. pgummadi@email.sc.edu.
Mayomi H OmebeyinjeDepartment of Environmental Health Sciences, University of South Carolina, Columbia, SC 29208, USA. mayomi@email.sc.edu.
Ananda M MondalDepartment of Mathematics and Computer Science, Claflin University, Orangeburg, SC 29115, USA. amondal@claflin.edu.
Dominic K BettDepartment of Mathematics and Computer Science, Claflin University, Orangeburg, SC 29115, USA. dbett@claflin.edu.
Sandra McFaddenDepartment of Environmental Health Sciences, University of South Carolina, Columbia, SC 29208, USA. sdmcfadden2011@gmail.com.
Sydney BromfieldDepartment of Environmental Health Sciences, University of South Carolina, Columbia, SC 29208, USA. bromfies@gmail.com.
Nora BanaszekDepartment of Environmental Health Sciences, University of South Carolina, Columbia, SC 29208, USA. banaszen@email.sc.edu.
Michelle Velez-MartinezDepartment of Environmental Health Sciences, University of South Carolina, Columbia, SC 29208, USA. velezmar@email.sc.edu.
Chandrani MitraDepartment of Environmental Health Sciences, University of South Carolina, Columbia, SC 29208, USA. cmitra@email.sc.edu.
Isabelle MikellDepartment of Environmental Health Sciences, University of South Carolina, Columbia, SC 29208, USA. immikell@yahoo.com.
Saurabh ChatterjeeEnvironmental Health and Disease Laboratory, Department of Environmental Health Sciences, University of South Carolina, Columbia, SC 29208, USA. schatt@mailbox.sc.edu.
Josephine WeeDivision of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA. jmw544@cornell.edu.
Anindya ChandaDepartment of Environmental Health Sciences, University of South Carolina, Columbia, SC 29208, USA. achanda@mailbox.sc.edu.
University of South Carolina · USClaflin University · USCornell University · USSouth Carolina Department of Health and Environmental Control · US

Funding

Use of Resveratrol to treat experimental multiple sclerosisP01AT003961 · NCCIH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI NAGARKATTI, PRAKASH S · 2007 to 2018
$14.2M
NCCIH NIH HHS P01 AT003961
6 · The paper itself

Abstract

An aspect of mycotoxin biosynthesis that remains unclear is its relationship with the cellular management of reactive oxygen species (ROS). Here we conduct a comparative study of the total ROS production in the wild-type strain (SU-1) of the plant pathogen and aflatoxin producer,

Indexed as

AflatoxinsAspergillusGene Expression Regulation, FungalMutationReactive Oxygen SpeciesSuperoxide DismutaseAflatoxinsReactive Oxygen SpeciesSuperoxide Dismutaseaflatoxinaflatoxin biosynthesisaflRand aflatoxin itself.an established model for studying mycotoxin biosynthesis and secondary metabolism in filamentous fungi. We show that activation of aflatoxin biosynthesis reduces total ROS production in this fungusAspergillusis jointly mediated by the aflatoxin pathway regulatorKey Contributionreactive oxygen speciessuperoxide dismutaseThis work illustrates how aflatoxin biosynthesis contributes to the management of total ROS in Aspergillus parasiticuswhich at least in part

Identifiers

PMID29382166
PMCPMC5848158
OpenAlexW2788245746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.