Evidence map›Paper›PMID 29382090›Full record

ReviewPathogens (Basel, Switzerland)2018

On the Demographic and Selective Forces Shaping Patterns of Human Cytomegalovirus Variation within Hosts.

Andrew M Sackman, Susanne P Pfeifer, Timothy F Kowalik, Jeffrey D Jensen

Abstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. A consideration of within-host human cytomegalovirus genetic variation.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  10. Reply to Jensen and Kowalik: Consideration of mixed infections is central to understanding HCMV intrahost diversity.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andrew M SackmanSchool of Life Sciences, Arizona State University, Tempe, AZ 85281, USA. sackman@asu.edu.
Susanne P PfeiferSchool of Life Sciences, Arizona State University, Tempe, AZ 85281, USA. susanne.pfeifer@asu.edu.
Timothy F KowalikDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA. timothy.kowalik@umassmed.edu.
Jeffrey D JensenSchool of Life Sciences, Arizona State University, Tempe, AZ 85281, USA. jeffrey.d.jensen@asu.edu.

Funding

Acquisition of HCMV from breast milk-correlates of protectionR01AI109001 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOPPANA, SURESH B · 2014 to 2017
$2.8M
NIAID NIH HHS R01 AI109001
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) is a member of the β -herpesvirus subfamily within Herpesviridae that is nearly ubiquitous in human populations, and infection generally results only in mild symptoms. However, symptoms can be severe in immunonaive individuals, and transplacental congenital infection of HCMV can result in serious neurological sequelae. Recent work has revealed much about the demographic and selective forces shaping the evolution of congenitally transmitted HCMV both on the level of hosts and within host compartments, providing insight into the dynamics of congenital infection, reinfection, and evolution of HCMV with important implications for the development of effective treatments and vaccines.

Indexed as

human cytomegaloviruspopulation geneticsviral evolution

Identifiers

PMID29382090
PMCPMC5874742

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.