Evidence map›Paper›PMID 29382065›Full record

ReviewBioengineering (Basel, Switzerland)2018

Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications.

Mulugeta Gizaw, Jeffrey Thompson, Addison Faglie, Shih-Yu Lee, Pierre Neuenschwander, Shih-Feng Chou

Open access · goldAbstract readReview
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 141 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. ACS applied polymer materials · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Emerging treatment strategies in wound care.International wound journal · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mulugeta GizawDepartment of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, Tyler, TX 75799, USA. mgizaw@patriots.uttyler.edu.
Jeffrey ThompsonDepartment of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, Tyler, TX 75799, USA. jthompson42@patriots.uttyler.edu.
Addison FaglieDepartment of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, Tyler, TX 75799, USA. AFaglie@patriots.uttyler.edu.
Shih-Yu LeeSchool of Nursing, College of Nursing and Health Sciences, The University of Texas at Tyler, Tyler, TX 75799, USA. ShihYuLee@uttyler.edu.
Pierre NeuenschwanderDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA. Pierre.Neuenschwander@uthct.edu.
Shih-Feng ChouDepartment of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, Tyler, TX 75799, USA. schou@uttyler.edu.
The University of Texas at Tyler · USThe University of Texas Health Science Center at Tyler · US

Funding

American Heart Association-American Stroke Association 18AIREA33960372
6 · The paper itself

Abstract

Wound healing is a complex tissue regeneration process that promotes the growth of new tissue to provide the body with the necessary barrier from the outside environment. In the class of non-healing wounds, diabetic wounds, and ulcers, dressing materials that are available clinically (e.g., gels and creams) have demonstrated only a slow improvement with current available technologies. Among all available current technologies, electrospun fibers exhibit several characteristics that may provide novel replacement dressing materials for the above-mentioned wounds. Therefore, in this review, we focus on recent achievements in electrospun drug-eluting fibers for wound healing applications. In particular, we review drug release, including small molecule drugs, proteins and peptides, and gene vectors from electrospun fibers with respect to wound healing. Furthermore, we provide an overview on multifunctional dressing materials based on electrospun fibers, including those that are capable of achieving wound debridement and wound healing simultaneously as well as multi-drugs loading/types suitable for various stages of the healing process. Our review provides important and sufficient information to inform the field in development of fiber-based dressing materials for clinical treatment of non-healing wounds.

Indexed as

compositesdrug releaseelectrospun fibersgene vectorsproteins and peptidessmall molecule drugs

Identifiers

PMID29382065
PMCPMC5874875
OpenAlexW2793289558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.