ArticleNutrients2018
Association of Circulating Vitamin E (α- and γ-Tocopherol) Levels with Gallstone Disease.
Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Association of dietary vitamin intake with gallstone risk in US adults: a cross-sectional NHANES study.European journal of medical research · 2025Article
- Association between dietary niacin intake and the odds of gallstones in US adults: A cross-sectional study in NHANES 2017-2020.Preventive medicine reports · 2025Article
- Dietary phytochemical index and the risk of gallstone disease: a case-control study.BMC gastroenterology · 2025Article
- Oxidative balance scores and gallstone disease: mediating effects of oxidative stress.Nutrition journal · 2025Article
- Higher levels of oxidative balance score linked to lower risk of gallstones: findings from the 2017-2020 National Health and Nutrition Examination Survey.Frontiers in nutrition · 2025Article
- The mediating role of body mass index in the association between unprocessed or minimally processed foods and gallstones.Frontiers in nutrition · 2025Article
- Association between oxidative balance score and gallstone disease: a population-based study from NHANES.Frontiers in nutrition · 2025Article
- Characterizing the relationships between dietary indices, gallstone prevalence and the need for gallbladder surgery in the general US population.Frontiers in nutrition · 2024Article
- Associations of 24 h urinary excretions of α- and γ-carboxyethyl hydroxychroman with plasma α- and γ-tocopherol and dietary vitamin E intake in older adults: the Lifelines-MINUTHE Study.European journal of nutrition · 2022Article
- Epidemiological survey to determine the prevalence of cholecystolithiasis in Uyghur, Kazakh, and Han Ethnic Groups in the Xinjiang Uyghur Autonomous Region of China: cross-sectional studies.BMC gastroenterology · 2021Article
- Dietary Total Antioxidant Capacity and Risk of Gall Stone: A Case-Control Study.International journal of preventive medicine · 2021Article
- Article
- Severe chronic bowel obstruction associated with brown bowel syndrome.SAGE open medical case reports · 2020Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In addition to well-established risk factors like older age, female gender, and adiposity, oxidative stress may play a role in the pathophysiology of gallstone disease. Since vitamin E exerts important anti-oxidative functions, we hypothesized that circulating vitamin E levels might be inversely associated with prevalence of gallstone disease. In a cross-sectional study, we measured plasma levels of α- and γ-tocopherol using high performance liquid chromatography in a community-based sample (582 individuals; median age 62 years; 38.5% women). Gallstone disease status was assessed by ultrasound. Multivariable-adjusted logistic regression models were used to estimate the association of circulating α- and γ-tocopherol/cholesterol ratio levels with prevalent gallstone disease. Lower probabilities of having gallstone disease were observed in the top (compared to the bottom) tertile of the plasma α-tocopherol/cholesterol ratio in multivariable-adjusted models (OR (Odds Ratio): 0.31; 95% CI (Confidence Interval): 0.13-0.76). A lower probability of having gallstone disease was also observed for the γ-tocopherol/cholesterol ratio, though the association did not reach statistical significance (OR: 0.77; 95% CI: 0.35-1.69 for 3rd vs 1st tertile). In conclusion, our observations are consistent with the concept that higher vitamin E levels might protect from gallstone disease, a premise that needs to be further addressed in longitudinal studies.
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