SynthesisMedicine2017
Association of diabetes mellitus with thyroid cancer risk: A meta-analysis of cohort studies.
Synthesis in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Association between prediabetes and thyroid cancer risk: A meta-analysis.Biomolecules & biomedicine · 2025Pooled it
- Pooled it
- Metformin and thyroid carcinoma incidence and prognosis: A systematic review and meta-analysis.PloS one · 2022Pooled it
- Different types of diabetes mellitus and risk of thyroid cancer: A meta-analysis of cohort studies.Frontiers in endocrinology · 2022Pooled it
- Development and validation of an intra-tumoral and peri-tumoral radiomics model based on dynamic contrast-enhanced ultrasound for predicting lymph node metastasis in type 2 diabetic patients with thyroid cancer.Frontiers in endocrinology · 2026Article
- Incorporation of clinical features into a multivariate logistic regression model for the differential diagnosis of benign and malignant TI-RADS 4 thyroid nodules.Frontiers in endocrinology · 2025Article
- Causal effects of autoimmune diseases on thyroid cancer: a two-sample Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Associations of Combined Exposure to Metabolic and Inflammatory Indicators with Thyroid Nodules in Adults: A Nested Case-Control Study.International journal of endocrinology · 2024Article
- Diabetes Mellitus and Thyroid Cancers: Risky Correlation, Underlying Mechanisms and Clinical Prevention.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Metabolic syndrome and thyroid Cancer: risk, prognosis, and mechanism.Discover oncology · 2023Review
- Putting GLP-1 RAs and Thyroid Cancer in Context: Additional Evidence and Remaining Doubts.Diabetes care · 2023Article
- Thyroid Cancer and Psoriasis: A Nested Case-Control Study.Diagnostics (Basel, Switzerland) · 2022Article
- Glucose Metabolism Derangements and Thyroid Nodules: Does Sex Matter?Journal of personalized medicine · 2022Article
- Insulin and cancer: a tangled web.The Biochemical journal · 2022Review
- Review
- Adherence to mediterranean diet and the risk of differentiated thyroid cancer in a European cohort: The EPIC study.Frontiers in nutrition · 2022Article
- The Relationship Between Diabetes Mellitus and Cancers and Its Underlying Mechanisms.Frontiers in endocrinology · 2022Review
- Fibrinogen-to-Neutrophil Ratio as a New Predictor of Central Lymph Node Metastasis in Patients with Papillary Thyroid Cancer and Type 2 Diabetes Mellitus.Cancer management and research · 2022Article
- Abnormal Glucose Metabolism Parameters and the Aggressiveness of Differentiated Thyroid Carcinoma: A Hospital-Based Cross-Section Study in China.Frontiers in endocrinology · 2022Observational
- Glucose-to-Lymphocyte Ratio (GLR) as a Predictor of Preoperative Central Lymph Node Metastasis in Papillary Thyroid Cancer Patients With Type 2 Diabetes Mellitus and Construction of the Nomogram.Frontiers in endocrinology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes mellitus (DM) is inconsistently associated with thyroid cancer risk. The purpose of this study was to summarize findings from cohort studies regarding the strength of the association of DM with subsequent thyroid cancer risk.
methodsElectronic searches were performed in PubMed, EmBase, and the Cochrane Library to identify studies from inception to July 2016. Cohort studies reporting risk estimates with 95% confidence intervals (CIs) of thyroid cancer in DM and non-DM patients were included. A random-effects meta-analysis was performed to the risk of thyroid cancer in DM compared with non-DM participants.
resultsSixteen cohort studies were included, with a total of 10,725,884 individuals. These studies reported a total of 8032 cases of thyroid cancer. Overall, DM was associated with an increased risk of thyroid cancer (relative risk [RR], 1.20; 95% CI, 1.09-1.33; P < .001). Further, there was no significant difference was found between DM and non-DM for the risk of thyroid cancer in men (RR, 1.14; 95% CI, 1.00-1.30; P = .057), while a significant correlation was found in a pooled analysis in women (RR, 1.11; 95% CI, 1.06-1.17; P < .001). Finally, subgroup analyses suggested that country and mean age might correlate with the relationship between DM and the risk of thyroid cancer.
conclusionThis study suggested that patients with DM have significantly increased risk of thyroid cancer compared nondiabetics. This positive association was prominent in women, and not significant in men. Further large-scale studies are required to verify the nature of the association, which should be evaluated in specific subpopulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.