Trial reportThe American journal of clinical nutrition2018
Evaluation of meal replacements and a home food environment intervention for long-term weight loss: a randomized controlled trial.
Trial report in The American journal of clinical nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01065974 (A Test of Nutritional Interventions to Enhance Weight Loss Maintenance), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Test of Nutritional Interventions to Enhance Weight Loss Maintenance
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meal replacements on obesity and leptin: a systematic review and meta-analysis.Reviews in endocrine & metabolic disorders · 2025Pooled it
- A systematic review and meta-analysis of the effectiveness of meal replacements for weight loss.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2019Pooled it
- Trial
- Meal replacement by formula diet reduces weight more than a lifestyle intervention alone in patients with overweight or obesity and accompanied cardiovascular risk factors-the ACOORH trial.European journal of clinical nutrition · 2021Trial
- Weight Change 2 Years After Termination of the Intensive Lifestyle Intervention in the Look AHEAD Study.Obesity (Silver Spring, Md.) · 2020Trial
- White Sweet Potato as Meal Replacement for Overweight White-Collar Workers: A Randomized Controlled Trial.Nutrients · 2019Trial
- Review
- Weight regain after total meal replacement very low-calorie diet program with and with-out anti-obesity medications.Obesity science & practice · 2024Article
- New insights in the mechanisms of weight-loss maintenance: Summary from a Pennington symposium.Obesity (Silver Spring, Md.) · 2023Review
- Study protocol for a randomized, controlled trial using a novel, family-centered diet treatment to prevent nonalcoholic fatty liver disease in Hispanic children.Contemporary clinical trials · 2023Article
- Spatiotemporal profile of altered neural reactivity to food images in obesity: Reward system is altered automatically and predicts efficacy of weight loss intervention.Frontiers in neuroscience · 2023Article
- The ironic effects of dietary restraint in situations that undermine self-regulation.Eating behaviors · 2021Article
- Weight variability during self-monitored weight loss predicts future weight loss outcome.International journal of obesity (2005) · 2020Article
- Use of people-first language with regard to obesity.The American journal of clinical nutrition · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Background: Lifestyle change treatments for weight loss produce medically meaningful weight reductions, but lost weight is usually regained. Meal replacements (MRs) represent one avenue for improving long-term weight loss. Another, nutrition-focused approach involves having participants make specific changes in the energy density, composition, and structure of the foods in their personal food environments. Objective: Three conditions were compared: behavior therapy (BT), BT plus MRs (BT+MR), and a nutrition-focused treatment aimed at modifying the home food environment (HFE). Design: Overweight and obese individuals (n = 262) were randomly assigned to 1 of the 3 conditions. Treatment occurred in weekly groups for 6 mo and in biweekly groups for 6 mo. Assessments were conducted at baseline and at 6, 12, 18, 24, and 36 mo. Multilevel models were used to estimate weight-change trajectories for each participant and to examine the treatment group effect on long-term weight loss. Results: A multilevel analysis indicated that all 3 groups showed significant weight loss over 12 mo that was gradually regained to the 36-mo follow-up. Mean ± SD percentages of baseline weight loss at 12 mo for BT, BT+MR, and HFE were 9.41% ± 7.92%, 10.37% ± 7.77%, and 10.97% ± 7.79%, respectively. Comparable percentages at 36 mo were 4.21% ± 8.64%, 3.06% ± 6.93%, and 4.49% ± 7.83%. Those in the HFE condition lost more weight than those receiving BT through the 36-mo assessment (P < 0.01), as reflected in 2 treatment × time interactions. Further analyses showed that HFE produced the largest increases in cognitive restraint and that this increase largely mediated the HFE group's improved weight loss. Conclusion: The nutrition-focused intervention studied here produced modestly greater long-term weight loss than BT, an effect that was largely explainable by an unexpected boost in cognitive restraint in this condition. This study was registered at clinicaltrials.gov as NCT01065974.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.