ArticlePloS one2018
Longitudinal changes in clinical characteristics and outcomes for children using long-term non-invasive ventilation.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Positive Airway Pressure and Metabolic Markers in Children With Obstructive Sleep Apnea.Respiratory care · 2024Pooled it
- Long-Term Non-invasive Ventilation in Children With Down Syndrome: A Systematic Review.Frontiers in pediatrics · 2022Pooled it
- Liberation and mortality outcomes in pediatric long-term ventilation: A qualitative systematic review.Pediatric pulmonology · 2020Pooled it
- Establishing polysomnographic criteria for initiation of non-invasive ventilation in children with neuromuscular diseases.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Clinical outcomes of paediatric home ventilation in South Korea: liberation and mortality.BMJ open respiratory research · 2026Article
- Home-Based Heated Humidified High-Flow Therapy for Respiratory Conditions: A Health Technology Assessment.Ontario health technology assessment series · 2025Article
- Article
- Post-acute day and night non-invasive respiratory intervention use and outcome: A brief report.Journal of pediatric rehabilitation medicine · 2024Article
- The experience of children using long-term non-invasive ventilation: a qualitative study.Frontiers in sleep · 2024Article
- Home mechanical ventilation in children with chronic respiratory failure: a narrative review.Journal of Yeungnam medical science · 2023Article
- Comparison of non-invasive ventilation use and outcomes in children with Down syndrome and other children using this technology.Frontiers in sleep · 2023Article
- Impact of COVID-19 pandemic on adherence to noninvasive ventilation in children.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- Article
- Characteristics and outcomes in children on long-term mechanical ventilation: the experience of a pediatric tertiary center in Rome.Italian journal of pediatrics · 2020Article
- Non-invasive Ventilation and CPAP Failure in Children and Indications for Invasive Ventilation.Frontiers in pediatrics · 2020Review
- Non-invasive Ventilation in Children With Neuromuscular Disease.Frontiers in pediatrics · 2020Review
- Equity, guidelines, and respiratory devices: Call to action for the Canadian health care system.Canadian family physician Medecin de famille canadienArticle
- Article
- Characteristics of Pediatric Patients With Home Mechanical Ventilation in a Japanese Regional Core Hospital.Pediatrics international : official journal of the Japan Pediatric SocietyArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo describe longitudinal trends in long-term non-invasive ventilation (NIV) use in children including changes in clinical characteristics, NIV technology, and outcomes.
methodsThis was a multicenter retrospective cohort of all children started on long-term NIV from 2005 to 2014. All children 0 to 18 years who used NIV continuously for at least 3 months were included. Measures and main outcomes were: 1) Number of children starting NIV; 2) primary medical condition; 3) medical complexity defined by number of comorbidities, surgeries and additional technologies; 4) severity of sleep disordered breathing measured by diagnostic polysomnography; 5) NIV technology and use; 6) reasons for NIV discontinuation including mortality. Data were divided into equal time periods for analysis.
resultsA total of 622 children were included in the study. Median age at NIV initiation was 7.8 years (range 0-18 years). NIV incidence and prevalence increased five and three-fold over the 10-year period. More children with neurological and cardio-respiratory conditions started NIV over time, from 13% (95%CI, 8%-20%) and 6% (95%CI, 3%-10%) respectively in 2005-2008 to 23% (95%CI, 18%-28%) and 9% (95%CI, 6%-14%, p = 0.008) in 2011-2014. Medical complexity and severity of the sleep-disordered breathing did not change over time. Overall, survival was 95%; mortality rates, however, rose from 3.4 cases (95% CI, 0.5-24.3) to 142.1 (95% CI 80.7-250.3, p<0.001) per 1000 children-years between 2005-2008 and 2011-2014. Mortality rates differed by diagnostic category, with higher rates in children with neurological and cardio-respiratory conditions.
conclusionsAs demonstrated in other centers, there was a significant increase in NIV prevalence and incidence rate. There was no increase in medical complexity or severity of the breathing abnormalities of children receiving long-term NIV over time. The mortality rate increased over time, maybe attributable to increased use of NIV for children with neurological and cardio-respiratory conditions.
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