Evidence map›Paper›PMID 29381736›Full record

ArticlePloS one2018

Virologic outcome among patients receiving antiretroviral therapy at five hospitals in Haiti.

Frantz Jean Louis, Josiane Buteau, Kesner François, Erin Hulland, Jean Wysler Domerçant, Chunfu Yang, Jacques Boncy, Robert Burris, Valerie Pelletier, Nicholas Wagar and 3 more

Abstract read
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Frantz Jean LouisCenters for Disease Control and Prevention, Port-au-Prince, Haiti.
Josiane ButeauLaboratoire National de Santé Publique, Ministère de la Santé Publique et de la Population, Port-au-Prince, Haiti.
Kesner FrançoisProgramme National de Lutte contre le SIDA, Ministère de la Santé Publique et de la Population, Port-au-Prince, Haiti.
Erin HullandCenters for Disease Control and Prevention, Atlanta, Georgia, United States of America.
Jean Wysler DomerçantCenters for Disease Control and Prevention, Port-au-Prince, Haiti.
Chunfu YangCenters for Disease Control and Prevention, Atlanta, Georgia, United States of America.
Jacques BoncyLaboratoire National de Santé Publique, Ministère de la Santé Publique et de la Population, Port-au-Prince, Haiti.
Robert BurrisCenters for Disease Control and Prevention, Port-au-Prince, Haiti.
Valerie PelletierCenters for Disease Control and Prevention, Port-au-Prince, Haiti.
Nicholas WagarCenters for Disease Control and Prevention, Atlanta, Georgia, United States of America.
Varough DeydeCenters for Disease Control and Prevention, Port-au-Prince, Haiti.
David W LowranceCenters for Disease Control and Prevention, Port-au-Prince, Haiti.
Macarthur CharlesCenters for Disease Control and Prevention, Port-au-Prince, Haiti.ORCID 0000-0002-3822-5737

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionViral load (VL) assessment is the preferred method for diagnosing and confirming virologic failure for patients on antiretroviral therapy (ART). We conducted a retrospective cross-sectional study to evaluate the virologic suppression rate among patients on ART for ≥6 months in five hospitals around Port-au-Prince, Haiti.

methodsPlasma VL was measured and patients with VL <1,000 copies/mL were defined as virologically suppressed. A second VL test was performed within at least six months of the first test. Factors associated with virologic suppression were analyzed using logistic regression models accounting for site-level clustering using complex survey procedures.

resultsData were analyzed for 2,313 patients on ART for six months or longer between July 2013 and February 2015. Among them, 1,563 (67.6%) achieved virologic suppression at the first VL test. A second VL test was performed within at least six months for 718 (31.0%) of the patients. Of the 459 patients with an initial HIV-1 RNA <1,000 copies/mL who had a second VL performed, 394 (85.8%) maintained virologic suppression. Virologic suppression was negatively associated with male gender (adjusted odds ratio [aOR]: 0.80, 95% CI: 0.74-0.0.86), 23 to 35 months on ART (aOR:0.72[0.54-0.96]), baseline CD4 counts of 201-500 cells/mm3 and 200 cells/mm3 or lower (aORs: 0.77 [0.62-0.95] and 0.80 [0.66-0.98], respectively), poor adherence (aOR: 0.69 [0.59-0.81]), and TB co-infection (aOR: 0.73 [0.55-0.97]).

conclusionsThis study showed that over two-thirds of the patients in this evaluation achieved virologic suppression after ≥ six months on ART and the majority of them remained suppressed. These results reinforce the importance of expanding access to HIV-1 viral load testing in Haiti for monitoring ART outcomes.

Indexed as

AdolescentAdultAnti-HIV AgentsChildChild, PreschoolFemaleHaitiHIV-1HIV InfectionsHumansInfantInfant, NewbornMaleMiddle AgedRNA, ViralViral LoadAnti-HIV AgentsRNA, Viral

Identifiers

PMID29381736
PMCPMC5790273

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.