ArticlePloS one2018
Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Organoid-guided evidence that umbilical cord MSC-derived extracellular vesicles restore alveolar repair in cigarette smoke-induced lung injury.Frontiers in cell and developmental biology · 2026Article
- Bone loss and increased bone marrow adiposity in ovary-intact and ovariectomized rats with chronic obstructive pulmonary disease.Journal of endocrinological investigation · 2025Article
- The impact of chronic obstructive pulmonary disease on bone strength.Journal of bone and mineral metabolism · 2024Review
- E-cigarette aerosol exposure effect on bone biomechanical properties in murine models.Journal of biomechanics · 2024Article
- Smoking and tetramer tryptase accelerate intervertebral disc degeneration by inducing METTL14-mediated DIXDC1 mMolecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- Associations between bone mineral density and chronic obstructive pulmonary disease.The Journal of international medical research · 2022Article
- Article
- Cigarette Smoke Exposure Inhibits Osteoclast Apoptosis via the mtROS Pathway.Journal of dental research · 2021Article
- Cigarette smoke inhalation impairs angiogenesis in early bone healing processes and delays fracture union.Bone & joint research · 2020Article
- Osteoporosis in a Rat Model Co-Exposed to Cigarette Smoke and Intermittent Hypoxia.International journal of chronic obstructive pulmonary disease · 2020Article
- Interleukin-17A Deficiency Attenuated Emphysema and Bone Loss in Mice Exposed to Cigarette Smoke.International journal of chronic obstructive pulmonary disease · 2020Article
- Connexin 43 hemichannels protect bone loss during estrogen deficiency.Bone research · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Smoking is a common risk factor for both chronic obstructive pulmonary disease (COPD) and osteoporosis. In patients with COPD, severe emphysema is a risk factor for vertebral fracture; however, the effects of smoking or emphysema on bone health remain largely unknown. We report bone deterioration in a mouse model of emphysema induced by nose-only cigarette smoke (CS) exposure. Unexpectedly, short-term exposure for 4-weeks decreased bone turnover and increased bone volume in mice. However, prolonged exposure for 20- and 40-weeks reversed the effects from suppression to promotion of bone resorption. This long-term CS exposure increased osteoclast number and impaired bone growth, while it increased bone volume. Strikingly, long-term CS exposure deteriorated bone quality of the lumbar vertebrae as illustrated by disorientation of collagen fibers and the biological apatite c-axis. This animal model may provide a better understanding of the mechanisms underlying the deterioration of bone quality in pulmonary emphysema caused by smoking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.