ArticlePloS one2018
Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Acinetobacter baumannii among horses entering a veterinary teaching hospital: The contemporary "Trojan Horse".
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- The Occurrence of Bacterial Infections in Equine Wounds and Abscesses in Horses from 2019 to 2023.Veterinary sciences · 2026Article
- Molecular Identification and Phenotypic Antimicrobial Resistance ofAntibiotics (Basel, Switzerland) · 2026Article
- Comparison of a Single-Shot Antibiotic Protocol Compared to a Conventional 5-Day Antibiotic Protocol in Equine Diagnostic Laparotomy Regarding Pre- and Postoperative Colonization with Multi-Drug-Resistant Indicator Pathogens.Antibiotics (Basel, Switzerland) · 2026Article
- Survey of the antimicrobial susceptibility ofThe Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- Preliminary Functional Analysis of the Gut Microbiome in Colic Horses.Animals : an open access journal from MDPI · 2024Article
- Predominance of enterotoxigenic Escherichia coli among ESBL/plasmid-mediated AmpC-producing strains isolated from diarrheic foals: a public health concern.Acta veterinaria Scandinavica · 2024Article
- Prevalence, risk factors, and characterisation of extended-spectrum β-lactamase -producing Enterobacterales (ESBL-E) in horses entering an equine hospital and description of longitudinal excretion.BMC veterinary research · 2024Article
- Rapid typing ofFrontiers in microbiology · 2024Article
- Multiple host colonization and differential expansion of multidrug-resistant ST25-Acinetobacter baumannii clades.Scientific reports · 2023Article
- Antimicrobial Resistance and Extended-Spectrum Beta-Lactamase Genes inPathogens (Basel, Switzerland) · 2023Article
- [Therapy-relevant antibiotic resistances in a One Health context].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2023Review
- Does colonization with MRSA, ESBL - producing Enterobacteriaceae, and/or Acinetobacter baumannii - increase the risk for postoperative surgical site infection?Veterinary medicine and science · 2023Article
- Genomic Diversity, Antimicrobial Susceptibility, and Biofilm Formation of ClinicalMicroorganisms · 2023Article
- Antibiotic prophylaxis and hospitalization of horses subjected to median laparotomy: gut microbiota trajectories and abundance increase ofFrontiers in microbiology · 2023Article
- Characterisation of and risk factors for extended-spectrum β-lactamase producing Enterobacterales (ESBL-E) in an equine hospital with a special reference to an outbreak caused by Klebsiella pneumoniae ST307:CTX-M-1.Acta veterinaria Scandinavica · 2022Article
- Multiresistant Gram-Negative Pathogens—A Zoonotic Problem.Deutsches Arzteblatt international · 2021Review
- A Pilot Randomised Clinical Trial Comparing a Short-Term Perioperative Prophylaxis Regimen to a Long-Term Standard Protocol in Equine Colic Surgery.Antibiotics (Basel, Switzerland) · 2021Article
- Third Generation Cephalosporin ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Frequency, Local Dynamics, and Genomic Characteristics of ESBL-ProducingFrontiers in microbiology · 2021Article
- Extended spectrum β lactamase-producing Enterobacteriaceae shedding by race horses in Ontario, Canada.BMC veterinary research · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathogens frequently associated with multi-drug resistant (MDR) phenotypes, including extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) and Acinetobacter baumannii isolated from horses admitted to horse clinics, pose a risk for animal patients and personnel in horse clinics. To estimate current rates of colonization, a total of 341 equine patients were screened for carriage of zoonotic indicator pathogens at hospital admission. Horses showing clinical signs associated with colic (n = 233) or open wounds (n = 108) were selected for microbiological examination of nostril swabs, faecal samples and wound swabs taken from the open wound group. The results showed alarming carriage rates of Gram-negative MDR pathogens in equine patients: 10.7% (34 of 318) of validated faecal specimens were positive for ESBL-E (94%: ESBL-producing Escherichia coli), with recorded rates of 10.5% for the colic and 11% for the open wound group. 92.7% of the ESBL-producing E. coli were phenotypically resistant to three or more classes of antimicrobials. A. baumannii was rarely detected (0.9%), and all faecal samples investigated were negative for Salmonella, both directly and after two enrichment steps. Screening results for the equine nostril swabs showed detection rates for ESBL-E of 3.4% among colic patients and 0.9% in the open wound group, with an average rate of 2.6% (9/340) for both indications. For all 41 ESBL-producing E. coli isolated, a broad heterogeneity was revealed using pulsed-field gel electrophoresis (PFGE) patterns and whole genome sequencing (WGS) -analysis. However, a predominance of sequence type complex (STC)10 and STC1250 was observed, including several novel STs. The most common genes associated with ESBL-production were identified as blaCTX-M-1 (31/41; 75.6%) and blaSHV-12 (24.4%). The results of this study reveal a disturbingly large fraction of multi-drug resistant and ESBL-producing E. coli among equine patients, posing a clear threat to established hygiene management systems and work-place safety of veterinary staff in horse clinics.
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