ArticleBritish journal of cancer2018
Geriatric assessment may help decision-making in elderly patients with inoperable, locally advanced non-small-cell lung cancer.
Article in British journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 45 citations in OpenAlex.
- Prevalence and predictors of frailty among older patients with lung cancer: a systematic review and meta-analysis.Journal of thoracic disease · 2026Article
- Associations Between G8 Geriatric Screening Score, Charlson Comorbidity Index, AI-Based Age Phenotype, and Overall Survival in Older Adults With Stage I-II Non-Small Cell Lung Cancer.International journal of radiation oncology, biology, physics · 2025Article
- Treatment outcomes in older patients presenting to a radiation oncology clinic based on an electronic health record-based frailty index.Journal of geriatric oncology · 2025Article
- Review
- Impact of a comprehensive geriatric assessment to manage elderly patients with locally advanced non-small-cell lung cancers: a multicenter prospective study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- Pulmonary rehabilitation improves lung function and exercise tolerance in elderly non-surgical NSCLC patients.American journal of cancer research · 2025Article
- Frailty and Cancer Prognosis.Current oncology reports · 2024Review
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- The FITNESS study: longitudinal geriatric assessment, treatment toxicity, and biospecimen collection to assess functional disability among older adults with lung cancer.Frontiers in aging · 2024Article
- Effects of Neoadjuvant Radiotherapy on Survival in Patients with Stage IIIA-N2 Non-Small-Cell Lung Cancer Following Pneumonectomy.Journal of clinical medicine · 2022Article
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- Trend of lung cancer surgery, hospital selection, and survival between 2005 and 2016 in South Korea.Thoracic cancer · 2022Article
- Trends in lung cancer incidence by age, sex and histology from 2012 to 2025 in Catalonia (Spain).Scientific reports · 2021Article
- Article
- The Electronic Frailty Index is Associated with Increased Infection and All-Cause Mortality Among Older Patients with Primary Lung Cancer: A Cohort Study.Clinical interventions in aging · 2021Article
- Practical implications to contemplate when considering radical therapy for stage III non-small-cell lung cancer.British journal of cancer · 2020Review
- Older adults with cancer and their caregivers - current landscape and future directions for clinical care.Nature reviews. Clinical oncology · 2020Review
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Authors and funding
15 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough concurrent chemoradiotherapy (cCRT) increases survival in patients with inoperable, locally advanced non-small-cell lung cancer (NSCLC), there is no consensus on the treatment of elderly patients. The aim of this study was to determine the prognostic value of the comprehensive geriatric assessment (CGA) and its ability to predict toxicity in this setting.
methodsWe enrolled 85 consecutive elderly (⩾75 years) participants, who underwent CGA and the Vulnerable Elders Survey (VES-13). Those classified as fit and medium-fit by CGA were deemed candidates for cCRT (platinum-based chemotherapy concurrent with thoracic radiation therapy), while unfit patients received best supportive care.
resultsFit (37%) and medium-fit (48%) patients had significantly longer median overall survival (mOS) (23.9 and 16.9 months, respectively) than unfit patients (15%) (9.3 months, log-rank P=0.01). In multivariate analysis, CGA groups and VES-13 were independent prognostic factors. Fit and medium-fit patients receiving cCRT (n=54) had mOS of 21.1 months (95% confidence interval: 16.2, 26.0). In those patients, higher VES-13 (⩾3) was associated with shorter mOS (16.33 vs 24.3 months, P=0.027) and higher risk of G3-4 toxicity (65 vs 32%, P=0.028).
conclusionsComprehensive geriatric assessment and VES-13 showed independent prognostic value. Comprehensive geriatric assessment may help to identify elderly patients fit enough to be treated with cCRT.
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