ArticleAging & mental health2019
Associations between subclinical depressive symptoms and reduced brain volume in middle-aged to older adults.
Article in Aging & mental health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05936697 (Neurofeedback Training to Improve Prefrontal Functioning in Older Adults With Subclinical Depression and Anxiety), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neurofeedback Training to Improve Prefrontal Functioning in Older Adults With Subclinical Depression and Anxiety: a Randomised Control Trial
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Depression and episodic memory across the adult lifespan: A meta-analytic review.Psychological bulletin · 2021Pooled it
- Neuroimaging Insight Into Fragile X-Associated Neuropsychiatric Disorders: Literature Review.Frontiers in psychiatry · 2021Pooled it
- tDCS reduces depression and state anxiety symptoms in older adults from the augmenting cognitive training in older adults study (ACT).Brain stimulationTrial
- Alzheimer's disease biomarkers in relation to non-cognitive domains within the intrinsic capacity framework: a narrative review.GeroScience · 2026Review
- Hippocampal Total, Subregion, and Subfield Volume Alterations in Late-Life Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Functional Breakdown of Temporoparietal Junction Interaction in High-depression Individuals: Evidence from Multi-Metric Connectomics.Brain structure & function · 2026Article
- Brain Structures Associated with Depression in Older Adults in the National Alzheimer's Coordinating Center Uniform Data Set.Journal of geriatric psychiatry and neurology · 2026Article
- Perceived stress mediates the association between orbitofrontal cortex grey matter volume and depressive symptoms in older women.Scientific reports · 2025Article
- Effects of depression and anxiety symptoms on cognitive inhibition: A cross-sectional study of structural and functional MRI evidence.Medicine · 2025Observational
- A comparison of the acute effects of high intensity interval training and moderate intensity continuous training on working memory and emotional state in adolescent women with subthreshold depression.Frontiers in public health · 2025Article
- Hippocampal subfield volume in older adults with and without mild cognitive impairment: Effects of worry and cognitive reappraisal.Neurobiology of aging · 2024Article
- Depressive symptoms and hippocampal volume in autosomal dominant Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Independent and combined effects of methamphetamine use disorders and APOEε4 allele on cognitive performance and brain morphometry.Addiction (Abingdon, England) · 2023Article
- Depressive Symptoms in Older Adults via Multimodal Markers on Magnetic Resonance Imaging: A Literature Review.JAR life · 2023Article
- Rostral anterior cingulate connectivity in older adults with subthreshold depressive symptoms: A preliminary study.Aging brain · 2023Article
- Depressive symptoms in cognitively unimpaired older adults are associated with lower structural and functional integrity in a frontolimbic network.Molecular psychiatry · 2022Review
- Depressive symptom profiles predict dementia onset and brain pathology in older persons. The AGES-Reykjavik study.Neurobiology of aging · 2022Article
- Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models.Neurobiology of stress · 2021Review
- Clinical Neuropsychological Evaluation in Older Adults With Major Depressive Disorder.Current psychiatry reports · 2021Review
- The Effects of Nordic Walking With Poles With an Integrated Resistance Shock Absorber on Cognitive Abilities and Cardiopulmonary Efficiency in Postmenopausal Women.Frontiers in aging neuroscience · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesThe associations between subclinical depressive symptoms, as well specific symptom subscales, on brain structure in aging are not completely elucidated. This study investigated the extent to which depressive symptoms were related to brain volumes in fronto-limbic structures in a sample of middle-aged to older adults.
methodEighty participants underwent structural neuroimaging and completed the Beck Depression Inventory, 2nd Edition (BDI-II), which comprises separate affective, cognitive, and somatic subscales. Gray matter volumes were extracted from the caudal and rostral anterior cingulate, posterior cingulate, hippocampus, and amygdala. Hierarchical regression models examined the relationship between brain volumes and (i) total depressive symptoms and (ii) BDI-II subscales were conducted.
resultsAfter adjusting for total intracranial volume, race, and age, higher total depressive symptoms were associated with smaller hippocampal volume (p = 0.005). For the symptom subscales, after controlling for the abovementioned covariates and the influence of the other symptom subscales, more somatic symptoms were related to smaller posterior cingulate (p = 0.025) and hippocampal (p < 0.001) volumes. In contrast, the affective and cognitive subscales were not associated with brain volumes in any regions of interest.
conclusionOur data showed that greater symptomatology was associated with smaller volume in limbic brain regions. These findings provide evidence for preclinical biological markers of major depression and specifically advance knowledge of the relationship between subclinical depressive symptoms and brain volume. Importantly, we observed variations by specific depressive symptom subscales, suggesting a symptom-differential relationship between subclinical depression and brain volume alterations in middle-aged and older individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.