ArticleThe journal of nutrition, health & aging2018
Peripheral Blood Leukocyte Telomere Length Is Associated with Age but Not Renal Function: A Cross-Sectional Follow-Up Study.
Article in The journal of nutrition, health & aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Pooled it
- Biological age acceleration and cardiovascular-kidney-metabolic syndrome progression: evidence from UK Biobank and NHANES.Renal failure · 2026Article
- Mediated roles of oxidative stress and kidney function to leukocyte telomere length and prognosis in chronic kidney disease.Renal failure · 2025Article
- Review
- Telomere Attrition in Chronic Kidney Diseases.Antioxidants (Basel, Switzerland) · 2023Review
- Association Between Baseline Buccal Telomere Length and Progression of Kidney Function: The Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- How metabolic acidosis and kidney disease may accelerate the aging process.European journal of clinical nutrition · 2020Review
- Common methods of biological age estimation.Clinical interventions in aging · 2017Review
Corrections and comments
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Authors and funding
26 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe aimed to evaluate the relationship between baseline renal function and changes in telomere length in Han Chinese.
methodsThe telomere restriction fragment (TRF) length of leukocytes in the peripheral blood was measured in healthy volunteers recruited in 2014. The estimated glomerular filtration rate (eGFR) was calculated based on serum creatinine (Scr) and serum cystatin C (CysC)-eGFRcys and eGFRScr-cys through the Cockcroft-Gault formula (eGFRC-G) or the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI / eGFRCKD-EPI) equation. The correlation between telomere length changes over time and renal function was analyzed.
resultsLeukocyte TRF lengths were negatively correlated to age (r = -0.393, p < 0.001) and serum CysC (r = -0.180, p < 0.01), while positively associated with eGFRCKD-EPI, eGFRC-G, eGFRcys, and eGFRScr-cys (r = 0.182, 0.122, 0.290, and 0.254 respectively, p < 0.01). The 3-year change of telomere length was 46 bp/years. When adjusted for age, the associations between telomere length changes and baseline, subsequent TRF lengths, and serum CysC were no longer present. No association was observed between TRF length changes and renal function.
conclusionThe rate of telomere length changes was affected by age and baseline telomere length. The telomere length changes might be important markers for aging.
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Registered trials
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