ReviewDevelopmental neurobiology2018
Folate action in nervous system development and disease.
Review in Developmental neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- A Systematic Review of Folate and the Human Enteric Microbiome: Biological Mechanisms and Clinical Implications.International journal of molecular sciences · 2026Pooled it
- Folate-Methionine Cycle Disruptions in ASD Patients and Possible Interventions: A Systematic Review.Genes · 2023Pooled it
- Magnitude and determinants of neural tube defect in Africa: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2021Pooled it
- Review
- Early Gut Microbiota and Metabolic Profiles of Neonatal Donkey Foals and a Comparative Study with Maternal Communities.Microorganisms · 2026Article
- Role of Folate Metabolism in Neurodegenerative Diseases: Insight from Experimental and Clinical Studies.Current nutrition reports · 2026Review
- Impact of Adjunctive Myo-Inositol and Magnesium Therapy on Paediatric Overactive Bladder: A Retrospective Analysis.Children (Basel, Switzerland) · 2026Article
- Vitamins as Modulators of Neurodegenerative Disease Pathways: Mechanisms and Therapeutic Perspectives.Nutrients · 2026Review
- Folic Acid Metabolism and Its Impact on Neurogenesis: Molecular Mechanisms and Therapeutic Potential.Molecular neurobiology · 2026Review
- Clinical Benefits and Safety of Multiple Micronutrient Supplementation During Preconception, Pregnancy, and Lactation: A Review.Nutrition reviews · 2025Review
- Folic Acid as a Molecule Protecting Cells from the Negative Effects of Ultraviolet Radiation-An In Vitro Study.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Red meat consumption in higher healthy eating index diets is associated with brain health critical nutritional adequacy, and fecal microbial diversity.Scientific reports · 2025Article
- Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk.Food science & nutrition · 2025Article
- Article
- Exploring the Association Between Glucose-6-Phosphate Dehydrogenase Deficiency and Autism Spectrum Disorder: A Narrative Review.Children (Basel, Switzerland) · 2025Review
- Folate from probiotic bacteria and its therapeutic applications.Archives of microbiology · 2025Review
- Arsenic unsettles the cerebellar balance between neurodegeneration and neurogenesis: reversal by folic acid.Apoptosis : an international journal on programmed cell death · 2025Article
- Constraint-based modeling of bioenergetic differences between synaptic and non-synaptic components of dopaminergic neurons in Parkinson's disease.Frontiers in computational neuroscience · 2025Article
- Multifunctional Applications of Lactic Acid Bacteria: Enhancing Safety, Quality, and Nutritional Value in Foods and Fermented Beverages.Foods (Basel, Switzerland) · 2024Review
- The unique presentation of the relationship between red blood cell folate and appendicular skeletal muscle mass: a cross-sectional study.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The vitamin folic acid has been recognized as a crucial environmental factor for nervous system development. From the early fetal stages of the formation of the presumptive spinal cord and brain to the maturation and maintenance of the nervous system during infancy and childhood, folate levels and its supplementation have been considered influential in the clinical outcome of infants and children affected by neurological diseases. Despite the vast epidemiological information recorded on folate function and neural tube defects, neural development and neurodegenerative diseases, the mechanisms of folate action in the developing neural tissue have remained elusive. Here we compiled studies that argue for a unique role for folate in nervous system development and function and its consequences to neural disease and repair. © 2018 Wiley Periodicals, Inc. Develop Neurobiol 78: 391-402, 2018.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.