Evidence map›Paper›PMID 29380485›Full record

ArticleHuman brain mapping2018

Neuromodulation with single-element transcranial focused ultrasound in human thalamus.

Wynn Legon, Leo Ai, Priya Bansal, Jerel K Mueller

4 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 162 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed, 5 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05147103 naenrolling by invitationnot on this mapstarted 2022, after this paper: background citation

Investigation of the Duration of Low-intensity Focused Ultrasound

TypeinterventionalSponsorVirginia Polytechnic Institute and State UniversityRan2022 to 2027Enrolled80ConditionsDevelopment of LIFU for Clinical PurposesArmsLow-Intensity Focused Ultrasound
NCT05331560 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Efficacy and Safety of Transcranial Pulse Stimulation (TPS) in Older Adults With Mild Neurocognitive Disorder - an Open-label Self-controlled Trial

TypeinterventionalSponsorThe University of Hong KongRan2020 to 2024Enrolled20ConditionsMild Neurocognitive DisorderArmsTranscranial Pulse Stimulation (TPS)
NCT05602467 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Efficacy of a 24-week Long Term Transcranial Pulse Stimulation (TPS) on Cognition and Brain Structure in Older Adults With Mild Neurocognitive Disorder (NCD)

TypeinterventionalSponsorThe University of Hong KongRan2022 to 2024Enrolled22ConditionsMild Neurocognitive DisorderArmsTranscranial Pulse Stimulation (TPS), Treatment as usual (TAU)
NCT07518927 naenrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Mapping Low-Intensity Focused Ultrasound (LIFU)-Evoked Brain Network Responses Using Intracranial Electrophysiological Recordings

TypeinterventionalSponsorUniversity of PennsylvaniaRan2026 to 2031Enrolled30ConditionsLow Intensity Focussed Ultrasound, Electrodes, ImplantedArmsLow Intensity Focused Ultrasound
3 · Its place in the literature

Who cites it

162 citing papers in PubMed, 5 syntheses or guidelines pooled it, 325 citations in OpenAlex.

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  19. Noninvasive Suppression of Responses to Threat Using Focused Ultrasonic Waves.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Wynn LegonDivision of Physical Therapy and Division of Rehabilitation Science, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0002-8761-3496
Leo AiDivision of Physical Therapy and Division of Rehabilitation Science, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota.
Priya BansalDivision of Physical Therapy and Division of Rehabilitation Science, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota.
Jerel K MuellerDivision of Physical Therapy and Division of Rehabilitation Science, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota.
University of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcranial focused ultrasound (tFUS) has proven capable of stimulating cortical tissue in humans. tFUS confers high spatial resolutions with deep focal lengths and as such, has the potential to noninvasively modulate neural targets deep to the cortex in humans. We test the ability of single-element tFUS to noninvasively modulate unilateral thalamus in humans. Participants (N = 40) underwent either tFUS or sham neuromodulation targeted at the unilateral sensory thalamus that contains the ventro-posterior lateral (VPL) nucleus of thalamus. Somatosensory evoked potentials (SEPs) were recorded from scalp electrodes contralateral to median nerve stimulation. Activity of the unilateral sensory thalamus was indexed by the P14 SEP generated in the VPL nucleus and cortical somatosensory activity by subsequent inflexions of the SEP and through time/frequency analysis. Participants also under went tactile behavioral assessment during either the tFUS or sham condition in a separate experiment. A detailed acoustic model using computed tomography (CT) and magnetic resonance imaging (MRI) is also presented to assess the effect of individual skull morphology for single-element deep brain neuromodulation in humans. tFUS targeted at unilateral sensory thalamus inhibited the amplitude of the P14 SEP as compared to sham. There is evidence of translation of this effect to time windows of the EEG commensurate with SI and SII activities. These results were accompanied by alpha and beta power attenuation as well as time-locked gamma power inhibition. Furthermore, participants performed significantly worse than chance on a discrimination task during tFUS stimulation.

Indexed as

Brain MappingAcoustic StimulationAdolescentAdultElectroencephalographyEvoked Potentials, SomatosensoryFemaleFourier AnalysisHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleThalamusUltrasonography, Doppler, TranscranialYoung Adulthumanneuromodulationsomatosensorythalamustranscranialultrasound

Identifiers

PMID29380485
PMCPMC6866487
OpenAlexW2791250514

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.