ReviewBiophysical reviews2018
Allowance for boundary sharpening in the determination of diffusion coefficients by sedimentation velocity: a historical perspective.
Review in Biophysical reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- A historical overview of the need for distinction between the attainment of thermodynamic equilibrium and a kinetic steady state in experimental studies.European biophysics journal : EBJ · 2026Review
- Quantifying the concentration dependence of sedimentation coefficients for globular macromolecules: a continuing age-old problem.Biophysical reviews · 2021Review
- Measuring Ultra-Weak Protein Self-Association by Non-ideal Sedimentation Velocity.Journal of the American Chemical Society · 2019Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
This review summarizes endeavors undertaken in the middle of last century to employ the Lamm equation for quantitative analysis of boundary spreading in sedimentation velocity experiments on globular proteins, thereby illustrating the ingenuity required to achieve that goal in an era when an approximate analytical solution of that nonlinear differential equation of second order provided the only means for its application. Application of procedures based on that approximate solution to simulated sedimentation velocity distributions has revealed a slight disparity (about 3%) between returned and input values of the diffusion coefficient-a discrepancy comparable with that of estimates obtained by current simulative analyses based on numerical solution of the Lamm equation. Although the massive technological developments in the gathering and treatment of sedimentation velocity data over the past three to four decades have changed dramatically the manner in which boundary spreading is analyzed, they have not led to any significant improvement in the accuracy of the diffusion coefficient thereby deduced.
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Registered trials
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