Evidence map›Paper›PMID 29380181›Full record

ArticleInternational journal of hematology2018

Classical Hodgkin lymphoma type post-transplant lymphoproliferative disorder in a kidney transplant recipient: a diagnostic pitfall.

Taro Mohri, Yoshihiro Ikura, Asako Hirakoso, Masashi Okamoto, Masakatsu Hishizawa, Akifumi Takaori-Kondo, Seiichi Kato, Shigeo Nakamura, Kai Yoshimura, Hidetoshi Okabe and 1 more

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In one paragraph

Article in International journal of hematology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Taro MohriDepartment of Pathology, Takatsuki General Hospital, Takatsuki, 569-1192, Japan.
Yoshihiro IkuraDepartment of Pathology, Takatsuki General Hospital, Takatsuki, 569-1192, Japan. ikura@ajk.takatsuki-hp.or.jp.ORCID http://orcid.org/0000-0001-8599-2245
Asako HirakosoDepartment of Pathology, Takatsuki General Hospital, Takatsuki, 569-1192, Japan.
Masashi OkamotoDepartment of Hematology, Takatsuki General Hospital, Takatsuki, Japan.
Masakatsu HishizawaDepartment of Hematology, Kyoto University Hospital, Kyoto, Japan.
Akifumi Takaori-KondoDepartment of Hematology, Kyoto University Hospital, Kyoto, Japan.
Seiichi KatoDepartment of Pathology and Laboratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Shigeo NakamuraDepartment of Pathology and Laboratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kai YoshimuraDepartment of Pathology, Takatsuki General Hospital, Takatsuki, 569-1192, Japan.
Hidetoshi OkabeDepartment of Pathology, Takatsuki General Hospital, Takatsuki, 569-1192, Japan.
Yasuhiro IwaiDepartment of Pathology, Takatsuki General Hospital, Takatsuki, 569-1192, Japan.
Takatsuki General Hospital · JPKyoto University Hospital · JPAichi Cancer Center · JPNagoya University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of classical Hodgkin lymphoma type post-transplant lymphoproliferative disorder (HL-PTLD) after kidney transplantation to highlight the difficulty of distinguishing this disorder from Hodgkin lymphoma-like PTLD (HL-like PTLD). Through this case report and literature review, we seek to clarify definitive pathologic features to differentiate these two conditions. A 38-year-old male kidney transplant recipient who had been receiving immunosuppressants was admitted to our hospital with unidentified high fever. Computed tomography images and blood tests indicated a lymphoproliferative disorder. Abdominal lymph node biopsy was performed, and microscopic examination revealed the presence of many large atypical cells in a background of dense T cell accumulation. The large, atypical cells were positive for Epstein-Barr Virus (EBV)-encoded small RNAs (EBER) in situ hybridization, EBV-LMP1, CD30 and PAX5, but negative for CD15, CD20 and CD45. Except for CD15-negativity, this immunohistochemical pattern was consistent with that of classical Hodgkin lymphoma. By close examination of the above immunoreactivities and the patient's subsequent chemosensitive clinical course, we finally made a diagnosis of HL-PTLD.

Indexed as

Kidney TransplantationAdultBiomarkersDiagnosis, DifferentialHematologic TestsHerpesvirus 4, HumanHodgkin DiseaseHumansImmunohistochemistryIn Situ HybridizationKi-1 AntigenLymph NodesLymphoproliferative DisordersMalePAX5 Transcription FactorPostoperative ComplicationsBiomarkersEBV-associated membrane antigen, Epstein-Barr virusEpstein-Barr virus encoded RNA 1Ki-1 AntigenPAX5 protein, humanPAX5 Transcription FactorRNA, ViralViral Matrix ProteinsClassical Hodgkin lymphomaImmunohistochemistryPost-transplant lymphoproliferative disorder

Identifiers

PMID29380181
OpenAlexW2791629752

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.