Evidence map›Paper›PMID 29380171›Full record

ArticleInflammopharmacology2018

Java Tea (Orthosiphon stamineus) protected against osteoarthritis by mitigating inflammation and cartilage degradation: a preclinical study.

Rubiatul Adawiyah Bokhari, Nur Adeelah Che Ahmad Tantowi, Seng Fong Lau, Suhaila Mohamed

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Inflammopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. A Life-threatening Cup of Tea: A Case Report and Literature Review.Journal of community hospital internal medicine perspectives · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. Natural Approach in Osteoarthritis Therapy.Recent advances in inflammation & allergy drug discovery · 2022
    Review
  9. Article
  10. Review
  11. Article
  12. Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rubiatul Adawiyah BokhariUPM-MAKNA Laboratory of Cancer Research, Institute of Bioscience, Universiti Putra Malaysia, UPM Serdang, 43400, Serdang, Selangor, Malaysia.
Nur Adeelah Che Ahmad TantowiUPM-MAKNA Laboratory of Cancer Research, Institute of Bioscience, Universiti Putra Malaysia, UPM Serdang, 43400, Serdang, Selangor, Malaysia.
Seng Fong LauFaculty of Veterinary Medicine, Universiti Putra Malaysia, UPM Serdang, Serdang, Malaysia.
Suhaila MohamedUPM-MAKNA Laboratory of Cancer Research, Institute of Bioscience, Universiti Putra Malaysia, UPM Serdang, 43400, Serdang, Selangor, Malaysia. suhaila.mohamed@gmail.com.ORCID http://orcid.org/0000-0002-2954-3821

Funding

Kementerian Pertanian dan Industri Asas Tani Malaysia NH1014D052
6 · The paper itself

Abstract

The effect of Orthosiphon stamineus aqueous (OSA) extract against osteoarthritis (OA) was investigated in explant cartilage culture and in postmenopausal OA rat model. Female rats were bilaterally ovariectomized (OVX). Osteoarthritis was induced after surgical recovery, by intra-articular injection of monosodium iodoacetate (MIA) into the right knee. Rats were grouped (n = 8) into: healthy sham control; non-treated OA; OA + diclofenac (positive control 5 mg/kg); and two doses OSA (150-300 mg/kg). After 4 weeks' treatment, rats were evaluated for OA-related parameters and biomarkers. The OSA reduced proteoglycan and ROS release from the cartilage explants under inflammatory (IL-1b) conditions. In the OA-induced rats' cartilages, the OSA downregulated the mRNA expressions for IL-1β, IL-6, IL-10, TNF-α, NF-κβ, NOS2, PTGS2, PTGER2, ACAN, COL2A1, MMP1, MMP13, ADAMTS4, ADAMTS5 and TIMP1, mostly dose-dependently. The OSA reduced the OA rats' serum levels for PGE

Indexed as

AnimalsArthritis, ExperimentalCartilage, ArticularDiclofenacDose-Response Relationship, DrugFemaleInflammationInjections, Intra-ArticularOrthosiphonOsteoarthritisOvariectomyPlant ExtractsPostmenopauseRatsRats, Sprague-DawleyDiclofenacPlant ExtractsArticular cartilageInflammationOrthosiphon stamineusOsteoarthritisOvariectomyRat

Identifiers

PMID29380171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.