Evidence map›Paper›PMID 29380142›Full record

ReviewCurrent hypertension reports2018

Therapeutic Inertia and Treatment Intensification.

Robina Josiah Willock, Joseph B Miller, Michelle Mohyi, Ahmed Abuzaanona, Meri Muminovic, Phillip D Levy

Registry-linked trialAbstract readReview
In one paragraph

Review in Current hypertension reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07547345 (Live Healthy Chicago - Community Pilot), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07547345 narecruitingnot on this mapstarted 2026, after this paper: background citation

Live Healthy Chicago - Community Pilot

TypeinterventionalSponsorRush University Medical CenterRan2026 to 2027Enrolled200ConditionsHypertensionArmsCommunity-Based Multidisciplinary Hypertension Management Program
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).Hypertension research : official journal of the Japanese Society of Hypertension · 2019
    Guideline
  2. Trial
  3. Trial
  4. Cluster-randomized controlled trial for the early promotion of clinic visits for untreated hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2021
    Trial
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Comparative Efficacy of Hypertension Management Strategies.The International journal of angiology : official publication of the International College of Angiology, Inc · 2024
    Article
  11. Observational
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Robina Josiah WillockDepartment of Community Health and Preventive Medicine, Morehouse School of Medicine, Atlanta, GA, USA.
Joseph B MillerDepartment of Emergency Medicine and Department of Internal Medicine, Henry Ford Hospital and Wayne State University, Detroit, MI, USA.
Michelle MohyiDepartment of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.
Ahmed AbuzaanonaDepartment of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.
Meri MuminovicDepartment of Emergency Medicine, Henry Ford Hospital, Detroit, MI, USA.
Phillip D LevyDepartment of Emergency Medicine and Integrative Biosciences Center, Wayne State University, 6135 Woodward Ave, Detroit, MI, 48202, USA. plevy@med.wayne.edu.

Funding

Research Desogn and Biostatistics CoreU54MD007588 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI MAYBERRY, ROBERT M · 2012 to 2018
$24.8M
TCC for Health Disparties: Informing & Influencing Health Policy and PracticeU54MD008173 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI SATCHER, DAVID · 2012 to 2016
$13.4M
MI-BP: mHealth to Improve Blood Pressure Control in Hypertensive African AmericansR01HL127215 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BUIS, LORRAINE R · 2016 to 2020
$3.0M
National Center for Research Resources Infrastructure for Clinical and Translational Research U54MD007588NHLBI NIH HHS 5R01HL127215NHLBI NIH HHS R01 HL127215NIMHD NIH HHS U54 MD007588NIMHD NIH HHS U54 MD008173NIMHD NIH HHS U54MD008173
6 · The paper itself

Abstract

purpose of reviewThis review aims to emphasize how therapeutic inertia, the failure of clinicians to intensify treatment when blood pressure rises or remains above therapeutic goals, contributes to suboptimal blood pressure control in hypertensive populations. RECENT

findingsStudies reveal that the therapeutic inertia is quite common and contributes to suboptimal blood pressure control. Quality improvement programs and standardized approaches to support antihypertensive treatment intensification are ways to combat therapeutic inertia. Furthermore, programs that utilize non-physician medical professionals such as pharmacists and nurses demonstrate promise in mitigating the effects of this important problem. Therapeutic inertia impedes antihypertensive management and requires a broad effort to reduce its effects. There is an ongoing need for renewed focus and research in this area to improve hypertension control.

Indexed as

Antihypertensive AgentsBlood PressureHumansHypertensionPatient Care ManagementTreatment FailureTreatment OutcomeAntihypertensive AgentsAntihypertensive therapyHTN managementHypertension controlTherapeutic inertiaTreatment intensification

Identifiers

PMID29380142
PMCPMC6452867

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.