ArticleThe European physical journal. E, Soft matter2018
Threshold response and bistability in gene regulation by small noncoding RNA.
Article in The European physical journal. E, Soft matter, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 0 citations in OpenAlex.
- Dynamical Mechanisms for Gene Regulation Mediated by Two Noncoding RNAs in Long-Term Memory Formation.Neural plasticity · 2021Article
- Computational Modeling of Oxidative Stress in Fatty Livers Elucidates the Underlying Mechanism of the Increased Susceptibility to Ischemia/Reperfusion Injury.Computational and structural biotechnology journal · 2018Article
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1 author at 1 institution in 1 country.
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Abstract
In this paper, we study through mathematical modelling the combined effect of transcriptional and translational regulation by proteins and small noncoding RNAs (sRNA) in a genetic feedback motif that has an important role in the survival of E. coli under stress associated with oxygen and energy availability. We show that subtle changes in this motif can bring in drastically different effects on the gene expression. In particular, we show that a threshold response in the gene expression changes to a bistable response as the regulation on sRNA synthesis or degradation is altered. These results are obtained under deterministic conditions. Next, we study how the gene expression is altered by additive and multiplicative noise which might arise due to probabilistic occurrences of different biochemical events. Using the Fokker-Planck formulation, we obtain steady-state probability distributions for sRNA concentration for the network motifs displaying bistability. The probability distributions are found to be bimodal with two peaks at low and high concentrations of sRNAs. We further study the variations in the probability distributions under different values of noise strength and correlations. The results presented here might be of interest for designing synthetic network for artificial control.
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