ArticleNeurology(R) neuroimmunology & neuroinflammation2018
Multiplex family with GAD65-Abs neurologic syndromes.
Article in Neurology(R) neuroimmunology & neuroinflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Familial Anti-N-Methyl-D-Aspartate Receptor Encephalitis-A Tale of Two Sisters.Annals of Indian Academy of Neurology · 2026Article
- HLA Class I Haplotype in Glutamic Acid Decarboxylase Antibody-Associated Neurological Disease.European journal of neurology · 2026Article
- Can Genetic Predisposition Play a Role in Anti-Glutamic Acid Decarboxylase (GAD) Autoimmunity? A Rare Presentation in Three Siblings.Case reports in immunology · 2026Article
- Autoimmune encephalitis-associated epilepsy.Nature reviews. Neurology · 2025Review
- Immunogenetic Studies in Patients With GAD-Positive Stiff-Person Syndrome Reveal Novel Lymphocytic Genes andNeurology(R) neuroimmunology & neuroinflammation · 2025Article
- Ten Years ofNeurology(R) neuroimmunology & neuroinflammation · 2025Article
- Recent advances in autoimmune encephalitis.Arquivos de neuro-psiquiatria · 2024Review
- Stiff-person syndrome and related disorders - diagnosis, mechanisms and therapies.Nature reviews. Neurology · 2024Review
- Stiff Person Spectrum Disorders-An Update and Outlook on Clinical, Pathophysiological and Treatment Perspectives.Biomedicines · 2023Review
- A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies.Brain : a journal of neurology · 2023Article
- Familial autoimmunity in neurological patients with GAD65 antibodies: an interview-based study.Journal of neurology · 2021Article
- Primary DQ effect in the association between HLA and neurological syndromes with anti-GAD65 antibodies.Journal of neurology · 2020Article
- Long-term outcomes in temporal lobe epilepsy with glutamate decarboxylase antibodies.Journal of neurology · 2020Article
- Cerebrospinal Fluid Findings of 36 Adult Patients with Autism Spectrum Disorder.Brain sciences · 2020Article
- Associations between HLA and autoimmune neurological diseases with autoantibodies.Auto- immunity highlights · 2020Review
- Pathophysiology of paraneoplastic and autoimmune encephalitis: genes, infections, and checkpoint inhibitors.Therapeutic advances in neurological disorders · 2020Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveNeurologic autoimmune syndromes associated with anti-glutamate acid decarboxylase 65 antibodies (GAD65-Abs) are rare and mostly sporadic.
methodsWe describe a niece and her aunt with GAD65-Abs neurologic syndromes. High-resolution HLA typing of Class I and Class II alleles was performed using next-generation sequencing.
resultsThe proband had cerebellar ataxia and probable limbic encephalitis features, whereas her niece had stiff-person syndrome. Both had a high titer of GAD65-Abs in serum and CSF and showed signs of inflammation in CSF. Both affected members carried the same rare recombinant DRB1*15:01:01∼DQA1*01:02:01∼DQB1*05:02:01 haplotype, which may or may not be involved in disease susceptibility. Of interest, other unaffected members of the family either had the same HLA haplotype but normal serum GAD65-Abs or had different HLA types but a high titer of serum GAD65-Abs without neurologic symptoms, suggesting cumulative effects.
conclusionsThis unique association strengthens the concept that hereditary factors, possibly including specific HLA haplotypes, play a role in neurologic syndromes associated with GAD65-Abs.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.