Evidence map›Paper›PMID 29379820›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2018

MS

Belinda J Kaskow, Thomas S Buttrick, Hans-Ulrich Klein, Charles White, Justin R Bourgeois, Russell J Ferland, Nikolaos Patsopoulos, Elizabeth M Bradshaw, Philip L De Jager, Wassim Elyaman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Common Risk Variants inKidney international reports · 2023
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Belinda J KaskowAnn Romney Center for Neurologic Diseases (B.J.K., T.S.B., N.P.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Center for Translational and Computational Neuroimmunology (H.-U.K., E.M.B., P.L.D.J., W.E.), Department of Neurology, Columbia University Medical Center, New York, NY; Program in Medical and Population Genetics (H.-U.K., C.W., E.M.B., P.L.D.J., W.E.), Broad Institute, Cambridge, MA; and Departments of Neuroscience and Experimental Therapeutics, and Neurology (J.R.B., R.J.F.), Albany Medical College, Albany, NY.
Thomas S ButtrickAnn Romney Center for Neurologic Diseases (B.J.K., T.S.B., N.P.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Center for Translational and Computational Neuroimmunology (H.-U.K., E.M.B., P.L.D.J., W.E.), Department of Neurology, Columbia University Medical Center, New York, NY; Program in Medical and Population Genetics (H.-U.K., C.W., E.M.B., P.L.D.J., W.E.), Broad Institute, Cambridge, MA; and Departments of Neuroscience and Experimental Therapeutics, and Neurology (J.R.B., R.J.F.), Albany Medical College, Albany, NY.
Hans-Ulrich KleinAnn Romney Center for Neurologic Diseases (B.J.K., T.S.B., N.P.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Center for Translational and Computational Neuroimmunology (H.-U.K., E.M.B., P.L.D.J., W.E.), Department of Neurology, Columbia University Medical Center, New York, NY; Program in Medical and Population Genetics (H.-U.K., C.W., E.M.B., P.L.D.J., W.E.), Broad Institute, Cambridge, MA; and Departments of Neuroscience and Experimental Therapeutics, and Neurology (J.R.B., R.J.F.), Albany Medical College, Albany, NY.
Charles WhiteAnn Romney Center for Neurologic Diseases (B.J.K., T.S.B., N.P.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Center for Translational and Computational Neuroimmunology (H.-U.K., E.M.B., P.L.D.J., W.E.), Department of Neurology, Columbia University Medical Center, New York, NY; Program in Medical and Population Genetics (H.-U.K., C.W., E.M.B., P.L.D.J., W.E.), Broad Institute, Cambridge, MA; and Departments of Neuroscience and Experimental Therapeutics, and Neurology (J.R.B., R.J.F.), Albany Medical College, Albany, NY.
Justin R BourgeoisAnn Romney Center for Neurologic Diseases (B.J.K., T.S.B., N.P.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Center for Translational and Computational Neuroimmunology (H.-U.K., E.M.B., P.L.D.J., W.E.), Department of Neurology, Columbia University Medical Center, New York, NY; Program in Medical and Population Genetics (H.-U.K., C.W., E.M.B., P.L.D.J., W.E.), Broad Institute, Cambridge, MA; and Departments of Neuroscience and Experimental Therapeutics, and Neurology (J.R.B., R.J.F.), Albany Medical College, Albany, NY.
Russell J FerlandAnn Romney Center for Neurologic Diseases (B.J.K., T.S.B., N.P.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Center for Translational and Computational Neuroimmunology (H.-U.K., E.M.B., P.L.D.J., W.E.), Department of Neurology, Columbia University Medical Center, New York, NY; Program in Medical and Population Genetics (H.-U.K., C.W., E.M.B., P.L.D.J., W.E.), Broad Institute, Cambridge, MA; and Departments of Neuroscience and Experimental Therapeutics, and Neurology (J.R.B., R.J.F.), Albany Medical College, Albany, NY.
Nikolaos PatsopoulosAnn Romney Center for Neurologic Diseases (B.J.K., T.S.B., N.P.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Center for Translational and Computational Neuroimmunology (H.-U.K., E.M.B., P.L.D.J., W.E.), Department of Neurology, Columbia University Medical Center, New York, NY; Program in Medical and Population Genetics (H.-U.K., C.W., E.M.B., P.L.D.J., W.E.), Broad Institute, Cambridge, MA; and Departments of Neuroscience and Experimental Therapeutics, and Neurology (J.R.B., R.J.F.), Albany Medical College, Albany, NY.
Elizabeth M BradshawAnn Romney Center for Neurologic Diseases (B.J.K., T.S.B., N.P.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Center for Translational and Computational Neuroimmunology (H.-U.K., E.M.B., P.L.D.J., W.E.), Department of Neurology, Columbia University Medical Center, New York, NY; Program in Medical and Population Genetics (H.-U.K., C.W., E.M.B., P.L.D.J., W.E.), Broad Institute, Cambridge, MA; and Departments of Neuroscience and Experimental Therapeutics, and Neurology (J.R.B., R.J.F.), Albany Medical College, Albany, NY.
Philip L De JagerAnn Romney Center for Neurologic Diseases (B.J.K., T.S.B., N.P.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Center for Translational and Computational Neuroimmunology (H.-U.K., E.M.B., P.L.D.J., W.E.), Department of Neurology, Columbia University Medical Center, New York, NY; Program in Medical and Population Genetics (H.-U.K., C.W., E.M.B., P.L.D.J., W.E.), Broad Institute, Cambridge, MA; and Departments of Neuroscience and Experimental Therapeutics, and Neurology (J.R.B., R.J.F.), Albany Medical College, Albany, NY.
Wassim ElyamanAnn Romney Center for Neurologic Diseases (B.J.K., T.S.B., N.P.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Center for Translational and Computational Neuroimmunology (H.-U.K., E.M.B., P.L.D.J., W.E.), Department of Neurology, Columbia University Medical Center, New York, NY; Program in Medical and Population Genetics (H.-U.K., C.W., E.M.B., P.L.D.J., W.E.), Broad Institute, Cambridge, MA; and Departments of Neuroscience and Experimental Therapeutics, and Neurology (J.R.B., R.J.F.), Albany Medical College, Albany, NY.

Funding

Altered CD4+ T cell function in relation to the AHI1 MS locusR01AI130547 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ELYAMAN, WASSIM · 2017 to 2021
$2.0M
NIAID NIH HHS R01 AI130547
6 · The paper itself

Abstract

objectiveTo study the influence of the Abelson helper integration site 1 (

methodsWe characterized the chromatin state of T cells in the MS-associated

resultsChromatin state analysis reveals that the LD block containing rs4896153, which is robustly associated with MS susceptibility (odds ratio 1.15,

conclusionsOur findings suggest that the effect of the

Identifiers

PMID29379820
PMCPMC5778810

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.