Trial reportBioMed research international2017
Lateral Ramus Cortical Bone Plate in Alveolar Cleft Osteoplasty with Concomitant Use of Buccal Fat Pad Derived Cells and Autogenous Bone: Phase I Clinical Trial.
Trial report in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02859025 (Lateral Ramus Cortical Bone Plate in Alveolar Cleft Osteoplasty), which is not on this map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lateral Ramus Cortical Bone Plate in Alveolar Cleft Osteoplasty: Concomitant Use of Buccal Fat Pad Derived Cells and Autogenous Bone in a Preliminary Study
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Clinical stem cell therapy in oral and craniofacial bone regeneration: a systematic review and meta-analysis.Frontiers in bioengineering and biotechnology · 2026Pooled it
- Stem Cell-Based Tissue Engineering for Cleft Defects: Systematic Review and Meta-Analysis.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2024Pooled it
- Bone Regeneration with Mesenchymal Stem Cells in Scaffolds: Systematic Review of Human Clinical Trials.Stem cell reviews and reports · 2024Pooled it
- New technologies in oral reconstructive medicine: Consensus report of the AAP/OF/SEPA Workshop.Journal of periodontology · 2026Article
- Mesenchymal Stem Cells in Oral and Maxillofacial Surgery: A Systematic Review of Clinical Applications and Regenerative Outcomes.Journal of clinical medicine · 2025Review
- Options for Regenerative Treatment with Bone Grafts in Children with Anterior Lip/Palate Cleft-A Review.Children (Basel, Switzerland) · 2025Review
- Stem Cell Therapy's Efficiency in Reconstructing Alveolar Clefts: A System Review and Meta-Analysis of Randomized Controlled Trials.Stem cells international · 2025Review
- Categories, applications, and potential of stem cells in bone regeneration: an overview.Frontiers in medicine · 2025Review
- The Buccal Fat Pad: A Unique Human Anatomical Structure and Rich and Easily Accessible Source of Mesenchymal Stem Cells for Tissue Repair.Bioengineering (Basel, Switzerland) · 2024Review
- Microfragmented Fat and Biphasic Calcium Phosphates for Alveolar Cleft Repair: Protocol for a Prospective, Nonblinded, First-in-Human Clinical Study.JMIR research protocols · 2024Article
- Bone Tissue Engineering (BTE) of the Craniofacial Skeleton, Part I: Evolution and Optimization of 3D-Printed Scaffolds for Repair of Defects.The Journal of craniofacial surgery · 2023Article
- Adult Mesenchymal Stem Cells from Oral Cavity and Surrounding Areas: Types and Biomedical Applications.Pharmaceutics · 2023Review
- Article
- Exosomes in craniofacial tissue reconstruction.Maxillofacial plastic and reconstructive surgery · 2022Review
- Use of stem cells in bone regeneration in cleft palate patients: review and recommendations.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2022Review
- Mesenchymal stromal cells: what have we learned so far about their therapeutic potential and mechanisms of action?Emerging topics in life sciences · 2021Review
- Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection.World journal of stem cells · 2021Review
- In Vitro Prevascularization of Self-Assembled Human Bone-Like Tissues and Preclinical Assessment Using a Rat Calvarial Bone Defect Model.Materials (Basel, Switzerland) · 2021Article
- Intraoral Bone Regeneration Using Stem Cells-What a Clinician Needs to Know: Based on a 15-Year MEDLINE Search.Frontiers in dentistry · 2021Review
- Alveolar cleft bone grafting: factors affecting case prognosis.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue regeneration has become a promising treatment for craniomaxillofacial bone defects such as alveolar clefts. This study sought to assess the efficacy of lateral ramus cortical plate with buccal fat pad derived mesenchymal stem cells (BFSCs) in treatment of human alveolar cleft defects. Ten patients with unilateral anterior maxillary cleft met the inclusion criteria and were assigned to three treatment groups. First group was treated with anterior iliac crest (AIC) bone and a collagen membrane (AIC group), the second group was treated with lateral ramus cortical bone plate (LRCP) with BFSCs mounted on a natural bovine bone mineral (LRCP+BFSC), and the third group was treated with AIC bone, BFSCs cultured on natural bovine bone mineral, and a collagen membrane (AIC+BFSC). The amount of regenerated bone was measured using cone beam computed tomography 6 months postoperatively. AIC group showed the least amount of new bone formation (70 ± 10.40%). LRCP+BFSC group demonstrated defect closure and higher amounts of new bone formation (75 ± 3.5%) but less than AIC+BFSC (82.5 ± 6.45%), suggesting that use of BFSCs within LRCP cage and AIC may enhance bone regeneration in alveolar cleft bone defects; however, the differences were not statistically significant. This clinical trial was registered at clinicaltrial.gov with NCT02859025 identifier.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.