ReviewFrontiers in cellular and infection microbiology2017
The Potential for Topical Probiotic Treatment of Chronic Rhinosinusitis, a Personal Perspective.
Review in Frontiers in cellular and infection microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05427695 (Topical Probiotic Sinus Irrigations for the Treatment of Chronic Rhinosinusitis), which is not on this map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Topical Probiotic Sinus Irrigations for the Treatment of Chronic Rhinosinusitis: a Double Blinded Randomized Controlled Trial
Who cites it
14 citing papers in PubMed.
- Evaluation of the efficacy of Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 on aspects of common cold infections in children attending day care: a randomised, double-blind, placebo-controlled clinical study.European journal of nutrition · 2020Trial
- Oral versus intranasal probiotics for nasal microbiome modulation: a comparative review of route-dependent mechanisms and clinical implications.Folia microbiologica · 2026Review
- TNF-α Expression and Plasma Cell and Macrophage Numbers in Traumatic Ulcers in a Rat Model Treated by Topical or Systemic ProbioticInternational journal of medical sciences · 2025Article
- Chronic Rhinosinusitis-Microbiological Etiology, Potential Genetic Markers, and Diagnosis.International journal of molecular sciences · 2024Review
- Olfactory impairment in Italian patients with chronic rhinosinusitis with nasal polyps: a patient-centered survey.Frontiers in allergy · 2024Article
- STAT4 Phosphorylation of T-helper Cells predicts surgical outcomes in Refractory Chronic Rhinosinusitis.medRxiv : the preprint server for health sciences · 2023Article
- Modulation of Gut Microbiome as a Therapeutic Modality for Auditory Disorders.Audiology research · 2023Review
- Review
- The differences in the number of fibroblasts and blood vessels after the topical and systemic administration ofVeterinary world · 2021Article
- Influence of the Microbiome on Chronic Rhinosinusitis With and Without Polyps: An Evolving Discussion.Frontiers in allergy · 2021Review
- Review
- Biofilms and inflammation in patients with chronic rhinosinusitis.Medicine and pharmacy reports · 2020Article
- Clinical Detection of Chronic Rhinosinusitis through Next-Generation Sequencing of the Oral Microbiota.Microorganisms · 2020Article
- Bacterial Flora of the Nose and Paranasal Sinuses Among Patients Over 65 Years Old with Chronic Rhinosinusitis Who Underwent Endoscopic Sinus Surgery.Clinical interventions in aging · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review describes the rationale for topical probiotic intervention, the obstacles we are facing and a strategy for future research in the use of probiotics to modify CRS symptoms and disease expression. Recent advances in molecular microbiology has revealed a plethora of microbial DNA in the nasal cavity and sinuses of healthy subjects as well as in chronic sinusitis (CRS) patients. An infection is today rather seen as an imbalance between the commensal microbiome and the bacterial pathogens, resulting in a reduction in commensal bacterial diversity, combined with an increase in the growth of microbes eliciting an inflammatory response. This will in turn lead to the clinical symptoms of sinusitis. Probiotics (microorganisms that confer a health benefit) can be used either as a form of living antibiotics treatment, or as an immune-modulatory intervention. Topical probiotics, which is the focus of this review, have shown efficacy in a limited number of trials in otitis media and tonsillitis, but to date not in CRS. Although bacterial interference capacity against pathogens can be determined in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.