ArticleSchizophrenia research. Cognition2015
Different P50 sensory gating measures reflect different cognitive dysfunctions in schizophrenia.
Article in Schizophrenia research. Cognition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- One-day tropisetron treatment improves cognitive deficits and P50 inhibition deficits in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- The hidden route: an exploratory study on autonomic influences in early phases of information processing.BMC psychology · 2025Article
- Sex difference in association between cognitive and P50 deficits in patients with chronic schizophrenia.Archives of women's mental health · 2023Article
- A Narrative Review of Speech and EEG Features for Schizophrenia Detection: Progress and Challenges.Bioengineering (Basel, Switzerland) · 2023Review
- Unveiling the Associations between EEG Indices and Cognitive Deficits in Schizophrenia-Spectrum Disorders: A Systematic Review.Diagnostics (Basel, Switzerland) · 2022Review
- Prepulse Inhibition and P50 Suppression in Relation to Creativity and Attention: Dispersed Attention Beneficial to Quantitative but Not Qualitative Measures of Divergent Thinking.Frontiers in psychiatry · 2022Article
- Comparative Analysis of Dopaminergic and Cholinergic Mechanisms of Sensory and Sensorimotor Gating in Healthy Individuals and in Patients With Schizophrenia.Frontiers in behavioral neuroscience · 2022Review
- Associations of the serum kynurenine pathway metabolites with P50 auditory gating in non-smoking patients with first-episode schizophrenia.Frontiers in psychiatry · 2022Article
- Smoking as a Common Modulator of Sensory Gating and Reward Learning in Individuals with Psychotic Disorders.Brain sciences · 2021Article
- Altered neural oscillations and behavior in a genetic mouse model of NMDA receptor hypofunction.Scientific reports · 2021Article
- Thirty years of translational research in Mobility Medicine: Collection of abstracts of the 2020 Padua Muscle Days.European journal of translational myology · 2020Article
- Is schizotypic maternal personality linked to sensory gating abilities during infancy?Experimental brain research · 2019Article
- Electrophysiological Evidence in Schizophrenia in Relation to Treatment Response.Frontiers in psychiatry · 2018Review
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Authors and funding
6 authors.
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Abstract
The P50 is an early component of auditory evoked potentials and a measure of sensory gating deficits. This evoked potential component is thought to be an important endophenotype candidate for schizophrenia. Recent research suggests that instead of the P50 ratio, S1 and S2 amplitudes should be evaluated for sensory gating. However, no studies have focused on the relationship between cognitive dysfunction and P50 sensory gating deficits using S1 and S2 amplitudes. The purpose of the present study was to investigate the association between the P50 ratio (S2/S1), S1 and S2 amplitudes, and neuropsychological cognitive domains using stepwise multiple linear regression analyses. Results demonstrated a significant relationship between executive functioning and the P50 ratio and between sustained attention and S2 amplitude, respectively. Our findings suggest that the P50 ratio and S2 amplitude reflect distinct neurophysiological substrates associated with different cognitive functions.
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