ArticleComputational and mathematical methods in medicine2017
The Role of the Innate Immune System in Oncolytic Virotherapy.
Article in Computational and mathematical methods in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Next-generation oncolytic virotherapy for lung cancer: bridging innovative vector engineering with clinical immunotherapy.Translational lung cancer research · 2026Review
- Article
- Deterministic and stochastic modeling for PDGF-driven gliomas reveals a classification of gliomas.Journal of mathematical biology · 2021Article
- Quantitative Systems Pharmacology Approaches for Immuno-Oncology: Adding Virtual Patients to the Development Paradigm.Clinical pharmacology and therapeutics · 2021Review
- Basic stochastic model for tumor virotherapy.Mathematical biosciences and engineering : MBE · 2020Article
- Backward Hopf bifurcation in a mathematical model for oncolytic virotherapy with the infection delay and innate immune effects.Journal of biological dynamics · 2019Article
- Investigating Macrophages Plasticity Following Tumour-Immune Interactions During Oncolytic Therapies.Acta biotheoretica · 2019Article
- Spatial Model for Oncolytic Virotherapy with Lytic Cycle Delay.Bulletin of mathematical biology · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The complexity of the immune responses is a major challenge in current virotherapy. This study incorporates the innate immune response into our basic model for virotherapy and investigates how the innate immunity affects the outcome of virotherapy. The viral therapeutic dynamics is largely determined by the viral burst size, relative innate immune killing rate, and relative innate immunity decay rate. The innate immunity may complicate virotherapy in the way of creating more equilibria when the viral burst size is not too big, while the dynamics is similar to the system without innate immunity when the viral burst size is big.
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Registered trials
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