ArticleArchives of medical science : AMS2018
Clinical and immunological effects of vitamin D supplementation during the pollen season in children with allergic rhinitis.
Article in Archives of medical science : AMS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Vitamin D Supplementation and Allergic Rhinitis: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Vitamin D Supplementation and Allergic Diseases during Childhood: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- Therapeutic effect of vitamin D supplementation on allergic rhinitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019Trial
- Effects of vitamin D supplements on frequency of CD4European journal of clinical nutrition · 2019Trial
- Vitamin D and allergic rhinitis: A mini-review.World journal of methodology · 2026Review
- The association of vitamin D deficiency with the severity of adenoid hypertrophy and allergic rhinitis in children: a retrospective observational study.Frontiers in nutrition · 2026Article
- The Impact of Vitamin-D Supplementation on Individuals with Allergic Rhinitis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Is there a rationale for supplementing with vitamin D patients under treatment with allergen immunotherapy?Annals of medicine · 2023Article
- Serum vitamin DJournal of thoracic disease · 2023Article
- The Long-Term Effect of Vitamin D Supplementation on Quality of Life in Persistent (Perennial) Allergic Rhinitis Patients.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- A systematic review and meta-analysis of the response of serum 25-hydroxyvitamin D concentration to vitamin D supplementation from RCTs from around the globe.European journal of clinical nutrition · 2020Article
- The Role of Vitamin D in Respiratory Allergies Prevention. Why the Effect Is so Difficult to Disentangle?Nutrients · 2020Review
- Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: a meta-analysis and experimental validation.Archives of medical science : AMS · 2020Review
- Klotho and vitamin D in multiple sclerosis: an Italian study.Archives of medical science : AMS · 2020Article
- Vitamin D and Serum Immunoglobulin E Levels in Allergic Rhinitis: A Case-control Study from Pakistan.Cureus · 2019Article
- Effects of Serum Vitamin D and Efficacy of Subcutaneous Immunotherapy in Adult Patients With Allergic Rhinitis.Allergy, asthma & immunology research · 2019Article
- Genes and metabolic pathway of sarcoidosis: identification of key players and risk modifiers.Archives of medical science : AMS · 2019Article
- Vitamin D at the intersection of health and disease: The immunomodulatory perspective.International journal of health sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionVitamin D deficiency has been proposed as a potential contributing factor in patients with allergic diseases. We compared the clinical and immunological effects of vitamin D supplementation to placebo during the pollen season in children with allergic rhinitis. MATERIAL AND
methodsThirty-eight children aged 5-12, sensitive to grass pollen, participated in a prospective, randomized, double-blind, placebo-controlled trial. Children received either vitamin D 1000 IU daily supplementation or placebo. We studied symptoms/medication score, lung function, exhaled nitric oxide concentration (FENO), methacholine bronchial provocation test and serum level of 25(OH)D, as well as; CD4+CD25+Foxp3+ cells, TLR4, IL-1, IL-6, TNF and the IL-10 and transforming growth factor β1 (TGF-β1) levels in cell culture supernatants.
resultsVitamin D therapy was effective in reduction of the symptoms/medication score (
conclusionsVitamin D 1000 IU as a supplementary treatment of grass pollen allergy in children with allergic rhinitis during the pollen season significantly reduced the symptoms/medication score. The study revealed an immunological effect of vitamin D.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.