ArticleFrontiers in physiology2017
Increased Contractile Function of Human Saphenous Vein Grafts Harvested by "No-Touch" Technique.
Article in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- No-touch vein grafts in coronary artery bypass surgery: a registry-based randomized clinical trial.European heart journal · 2025Trial
- Stable Hemodynamics within "No-Touch" Saphenous Vein Graft.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2020Trial
- Lactate orchestrates metabolic hemodynamic adaptations through a unique combination of venocontraction, artery relaxation, and positive inotropy.Acta physiologica (Oxford, England) · 2025Article
- Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility.Basic research in cardiology · 2023Article
- Impact of Age on Endothelial Function of Saphenous Vein Grafts in Coronary Artery Bypass Grafting.Journal of clinical medicine · 2023Article
- Pragmatic Tips for Improving the Modern Outcomes of Coronary Artery Bypass Operations.The journal of Tehran Heart Center · 2022Article
- Saphenous Vein Vasa Vasorum as a Potential Target for Perivascular Fat-Derived Factors.Brazilian journal of cardiovascular surgery · 2020Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Saphenous vein grafts are the most common conduits used for coronary artery bypass grafting (CABG); however, no more than 60% of vein grafts remain open after 10 years and graft failure is associated with poor clinical outcome. The "no-touch" harvesting technique-where a sheet of perivascular tissue is retained around the vein-improves graft patency to over 80% after 16 years of follow-up, but the mechanism for the improved patency rate is unclear. In this study, we investigated acute functional differences between vein grafts harvested conventionally and by "no-touch" technique and explored the importance of perivascular tissue for reducing surgical trauma, minimizing excessive distension, and releasing vasoactive paracrine factors. Segments of human saphenous veins were obtained from CABG surgery and their functional properties investigated by isometric and isobaric myography. We found a broad diameter-tension relationship for human saphenous veins, with peak capacity for active tension development at diameters corresponding to transmural pressures around 60 mmHg. Across the investigated transmural pressure range between 10 and 120 mmHg, maximal tension development was higher for "no-touch" compared to conventionally harvested saphenous veins. Contractile responses to serotonin, noradrenaline, and depolarization induced with elevated extracellular [K
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