ArticleFrontiers in aging neuroscience2017
Ventricular and Periventricular Anomalies in the Aging and Cognitively Impaired Brain.
Article in Frontiers in aging neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 54 citations in OpenAlex.
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- Impact of Semaglutide on Hippocampal Injury in a Streptozotocin-Induced Model of Alzheimer's Disease.Biomedicines · 2026Article
- The case for space as a model of accelerated aging.Nature aging · 2026Review
- Ventricular enlargement is associated with early Alzheimer's disease pathophysiology.Brain communications · 2026Article
- MRI signature of brain age underlying post-traumatic stress disorder in World Trade Center responders.Translational psychiatry · 2025Article
- Ectopic recruitment of neuroblasts in striatal myelin bundles and nucleus accumbens following AraC chemical lesion.Stem cell reports · 2025Article
- Assessment of Brain Morphological Abnormalities and Neurodevelopmental Risk Copy Number Variants in Individuals from the UK Biobank.International journal of molecular sciences · 2025Article
- Dissection of Neurotropic Theiler's Murine Encephalomyelitis Virus Induced Brain Atrophy in Single MHC Class I Mice of C57BL/6 Background.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Experimental Ischemic Stroke Induces Secondary Bihemispheric White Matter Degeneration and Long-Term Cognitive Impairment.Translational stroke research · 2025Article
- White matter microstructure in obesity and bipolar disorders: an ENIGMA bipolar disorder working group study in 2186 individuals.Molecular psychiatry · 2025Article
- Boiled Sausage Sign: A Novel MRI Marker for Identifying Subacute Secondary Hydrocephalus in the Elderly.Cureus · 2025Article
- Abnormal choroid plexus, hippocampus, and lateral ventricles volumes as markers of treatment-resistant major depressive disorder.Psychiatry and clinical neurosciences · 2025Article
- A review of applications of automated ventricular parcellation from magnetic resonance imaging of the brain.Frontiers in neurology · 2025Review
- Effects of Carotid plaque Crouse score and serum Hcy on the location of white matter hyperintensities.Frontiers in neurology · 2025Article
- Evidence of clinical and brain recovery in post-COVID-19 condition: a three-year follow-up study.Brain communications · 2025Article
- Multiciliated ependymal cells: an update on biology and pathology in the adult brain.Acta neuropathologica · 2024Review
- A deep neural network estimation of brain age is sensitive to cognitive impairment and decline.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2024Article
- Aging and urinary control: Alterations in the brain-bladder axis.Aging cell · 2023Review
- Mechanical loading of the ventricular wall as a spatial indicator for periventricular white matter degeneration.Journal of the mechanical behavior of biomedical materials · 2023Article
- The Olfactory Bulb in Companion Animals-Anatomy, Physiology, and Clinical Importance.Brain sciences · 2023Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Ventriculomegaly (expansion of the brain's fluid-filled ventricles), a condition commonly found in the aging brain, results in areas of gliosis where the ependymal cells are replaced with dense astrocytic patches. Loss of ependymal cells would compromise trans-ependymal bulk flow mechanisms required for clearance of proteins and metabolites from the brain parenchyma. However, little is known about the interplay between age-related ventricle expansion, the decline in ependymal integrity, altered periventricular fluid homeostasis, abnormal protein accumulation and cognitive impairment. In collaboration with the Baltimore Longitudinal Study of Aging (BLSA) and Alzheimer's Disease Neuroimaging Initiative (ADNI), we analyzed longitudinal structural magnetic resonance imaging (MRI) and subject-matched fluid-attenuated inversion recovery (FLAIR) MRI and periventricular biospecimens to map spatiotemporally the progression of ventricle expansion and associated periventricular edema and loss of transependymal exchange functions in healthy aging individuals and those with varying degrees of cognitive impairment. We found that the trajectory of ventricle expansion and periventricular edema progression correlated with degree of cognitive impairment in both speed and severity, and confirmed that areas of expansion showed ventricle surface gliosis accompanied by edema and periventricular accumulation of protein aggregates, suggesting impaired clearance mechanisms in these regions. These findings reveal pathophysiological outcomes associated with normal brain aging and cognitive impairment, and indicate that a multifactorial analysis is best suited to predict and monitor cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.