ArticleFrontiers in molecular neuroscience2017
Brain Lateralization in Mice Is Associated with Zinc Signaling and Altered in Prenatal Zinc Deficient Mice That Display Features of Autism Spectrum Disorder.
Article in Frontiers in molecular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Left and Right Hemispheric Lateralization as an Overlooked Variable in Psychiatric Disease: Evidence Across Species.Biological psychiatry · 2026Review
- The Balance in the Head: How Developmental Factors Explain Relationships Between Brain Asymmetries and Mental Diseases.Brain sciences · 2025Review
- Postnatal zinc deficiency due to giardiasis disrupts hippocampal and cerebellar development.PLoS neglected tropical diseases · 2024Article
- Valproic acid exposure affects social visual lateralization and asymmetric gene expression in zebrafish larvae.Scientific reports · 2024Article
- Neurodevelopmental Consequences of Dietary Zinc Deficiency: A Status Report.Biological trace element research · 2023Review
- The Rationale for Vitamin, Mineral, and Cofactor Treatment in the Precision Medical Care of Autism Spectrum Disorder.Journal of personalized medicine · 2023Review
- Identification of the common neurobiological process disturbed in genetic and non-genetic models for autism spectrum disorders.Cellular and molecular life sciences : CMLS · 2022Article
- Prenatal Zinc Deficient Mice as a Model for Autism Spectrum Disorders.International journal of molecular sciences · 2022Review
- Are Essential Trace Elements Effective in Modulation of Mental Disorders? Update and Perspectives.Biological trace element research · 2022Review
- Exposure to GABAFrontiers in psychiatry · 2022Article
- Zinc is a key regulator of gastrointestinal development, microbiota composition and inflammation with relevance for autism spectrum disorders.Cellular and molecular life sciences : CMLS · 2021Article
- S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis.Translational psychiatry · 2021Article
- Altered offspring neurodevelopment in an arginine vasopressin preeclampsia model.Translational psychiatry · 2021Article
- Zinc.Advances in food and nutrition research · 2021Review
- Zinc and Copper Brain Levels and Expression of Neurotransmitter Receptors in Two Rat ASD Models.Frontiers in molecular neuroscience · 2021Article
- Early life metal exposure dysregulates cellular bioenergetics in children with regressive autism spectrum disorder.Translational psychiatry · 2020Article
- Hippocampal Metabolite Profiles in Two Rat Models of Autism: NMR-Based Metabolomics Studies.Molecular neurobiology · 2020Article
- Resting-State Co-activation Patterns as Promising Candidates for Prediction of Alzheimer's Disease in Aged Mice.Frontiers in neural circuits · 2020Article
- Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in theTranslational neurodegeneration · 2019Article
- Building an Asymmetrical Brain: The Molecular Perspective.Frontiers in psychology · 2019Review
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10 authors.
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Abstract
A number of studies have reported changes in the hemispheric dominance in autism spectrum disorder (ASD) patients on functional, biochemical, and morphological level. Since asymmetry of the brain is also found in many vertebrates, we analyzed whether prenatal zinc deficient (PZD) mice, a mouse model with ASD like behavior, show alterations regarding brain lateralization on molecular and behavioral level. Our results show that hemisphere-specific expression of marker genes is abolished in PZD mice on mRNA and protein level. Using magnetic resonance imaging, we found an increased striatal volume in PZD mice with no change in total brain volume. Moreover, behavioral patterns associated with striatal lateralization are altered and the lateralized expression of dopamine receptor 1 (DR1) in the striatum of PZD mice was changed. We conclude that zinc signaling during brain development has a critical role in the establishment of brain lateralization in mice.
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