ArticleTherapeutics and clinical risk management2018
Raised serum uric acid is associated with higher bone mineral density in a cross-sectional study of a healthy Indian population.
Article in Therapeutics and clinical risk management, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Analyses of the relationship between hyperuricemia and osteoporosis.Scientific reports · 2021Trial
- Antibacterial, antioxidant, and xanthine-oxidase inhibitory screening studies of selected cyperaceae species occurring in Europe.Biologia futura · 2026Article
- U-Shaped association between apolipoprotein A1 and serum uric acid levels in patients with osteoporotic fractures: a cross-sectional study.Frontiers in endocrinology · 2025Article
- BMI mediates the association of serum uric acid with bone health: a cross-sectional study of the National Health and Nutrition Examination Survey (NHANES).BMC musculoskeletal disorders · 2024Article
- Relationship between serum uric acid levels and osteoporosis.Endocrine connections · 2023Review
- Association of serum uric acid levels with bone mineral density and the presence of osteoporosis in Chinese patients with Parkinson's disease: a cross-sectional study.Journal of bone and mineral metabolism · 2023Article
- Bone mass in Saudi women aged 20-40 years: the association with obesity and vitamin D deficiency.Archives of osteoporosis · 2022Article
- Serum Uric Acid Level Is Positively Associated With Higher Bone Mineral Density at Multiple Skeletal Sites Among Healthy Qataris.Frontiers in endocrinology · 2021Article
- Association of Serum Uric Acid Status With Bone Mineral Density in Adolescents Aged 12-19 Years.Frontiers in medicine · 2020Article
- Specific higher levels of serum uric acid might have a protective effect on bone mineral density within a Chinese population over 60 years old: a cross-sectional study from northeast China.Clinical interventions in aging · 2019Article
- Prevalence of osteoporosis and osteopenia in an apparently healthy Indian population - a cross-sectional retrospective study.Osteoporosis and sarcopenia · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOxidative stress has been implicated as a fundamental mechanism in the decline of bone mass. Reactive oxygen species are reported to suppress osteoblast generation and differentiation and enhance osteoclast development and activity. Increasing evidence suggests favorable effect of serum uric acid (UA) on bone metabolism due to its antioxidant properties. Therefore, we investigated the association between serum UA levels and bone mineral density (BMD) in healthy adult Indian subjects. MATERIALS AND
methodsWe reviewed the medical records of 524 subjects who had undergone preventive health check-ups in a tertiary care hospital that included UA and BMD measurements at femur neck, total femur, and lumbar spine. Subjects concomitantly taking drugs or having a medical condition that would affect the bone metabolism or UA levels were excluded.
resultsThe final analysis included 310 subjects (mean age: 47.2±12.2 years; females: 43.5%; males: 56.5%). Study population was categorized into two groups based on the group median value for UA (ie, 5.4 mg/dL). BMD was significantly higher at all skeletal sites in subjects with UA >5.4 mg/dL compared to subjects with UA ≤5.4 mg/dL (
conclusionWe conclude that raised UA levels are associated with higher BMD at all skeletal sites and UA may have a protective role in bone metabolism owing to its antioxidant effect.
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