Evidence map›Paper›PMID 29379213›Full record

ReviewNature reviews. Immunology2018

Epigenetic control of CD8

Amanda N Henning, Rahul Roychoudhuri, Nicholas P Restifo

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 350 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
350citing papers in PubMed, 1 pooled it
16.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

350 citing papers in PubMed, 1 synthesis or guideline pooled it, 497 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. T Cell Thoughts.Immunological reviews · 2026
    Review
  8. Article
  9. IL-21 controls CD8Zoological research · 2026
    Article
  10. Review
  11. BATF3 regulates differentiation of CD8Life science alliance · 2026
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Jump-starting the T cell response in established tumors.bioRxiv : the preprint server for biology · 2026
    Article
  17. Review
  18. Stem-like PD-1Journal for immunotherapy of cancer · 2026
    Article
  19. Post-Translational Regulation of CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  20. Article

290 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Amanda N HenningCenter for Cell-Based Therapy, National Cancer Institute (NCI).
Rahul RoychoudhuriLaboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge CB22 3AT, UK.
Nicholas P RestifoCenter for Cell-Based Therapy, National Cancer Institute (NCI).
Babraham Institute · GBNational Cancer Institute · MYNational Institutes of Health · US

Funding

Building on the success of the adoptive immunotherapy of cancerZIABC010763 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ROSENBERG, STEVEN · 2009 to 2020
$25.0M
Building on the success of the adoptive immunotherapy of cancerZ01BC010763 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI RESTIFO, NICHOLAS P · 2006 to 2008
$6.4M
Biotechnology and Biological Sciences Research Council BB/N007794/1Biotechnology and Biological Sciences Research Council BBS/E/B/000C0407Biotechnology and Biological Sciences Research Council BBS/E/B/000C0409Cancer Research UK 22597Intramural NIH HHS Z01 BC010763Wellcome Trust
6 · The paper itself

Abstract

Upon stimulation, small numbers of naive CD8

Indexed as

AnimalsCD8-Positive T-LymphocytesCell DifferentiationCellular Reprogramming TechniquesChromatin Assembly and DisassemblyDNA MethylationEnhancer Elements, GeneticEpigenesis, GeneticHistone CodeHumansImmunotherapyModels, GeneticModels, ImmunologicalTranscription, Genetic

Identifiers

PMID29379213
PMCPMC6327307
OpenAlexW2785594347

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.