ArticleNature microbiology2018
AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling.
Abstract read
In one paragraph
Article in Nature microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 3 pooled it
22.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
111 citing papers in PubMed, 3 syntheses or guidelines pooled it, 166 citations in OpenAlex.
- Pooled it
- A systematic review of CRISPR applications in demyelinating peripheral nervous system disorders.Regenerative medicine · 2025Pooled it
- The Multifaceted Roles of TAM Receptors during Viral Infection.Virologica Sinica · 2021Pooled it
- Review
- Arboviral infections of the central nervous system: Mechanisms of invasion and long-term consequences.Journal of neurovirology · 2026Review
- Cellular receptors and host factors mediating orthoflavivirus entry.Virology journal · 2026Review
- SLC3A2 promotes early-stage of Zika virus infection in human placental cells and astrocytes.Infectious diseases & immunity · 2026Article
- Regnase-1-mediated regulation of neutrophils modulates SARS-CoV-2 pneumonia.PLoS pathogens · 2026Article
- Pathogenic breaches: how viruses compromise blood-tissue barriers.Tissue barriers · 2026Review
- Interplay between flaviviruses and the interferon response: mechanisms of immune evasion and therapeutic implications.Frontiers in pharmacology · 2026Review
- SFTSV utilizes AXL/GAS6 for entry via PI3K-PLC-dependent macropinocytosis activated by AXL-kinase.Journal of virology · 2025Article
- SOCS Proteins: Key Players in Immune Regulation During SARS-CoV-2 Infection.European journal of immunology · 2025Review
- The human neural cell atlas of Zika virus infection in developing brain tissue.Cell reports. Medicine · 2025Article
- Autophagy-mediated downregulation of AXL and TIM-1 promotes sustained Zika virus infection.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A single mutation in the PrM gene of Zika virus determines AXL dependency for infection of human neural cells.Journal of virology · 2025Article
- RNF149 modulates the type I IFN innate antiviral immune responses through degrading IRF3.PLoS pathogens · 2025Article
- Distinct ZIKV strain signatures and type I IFN modulation reveal a protective role of brain endothelial interferon signalingFrontiers in cellular and infection microbiology · 2025Article
- ITGB4/CD104 mediates zika virus attachment and infection.Nature communications · 2024Article
- Epidemic Zika virus strains from the Asian lineage induce an attenuated fetal brain pathogenicity.Nature communications · 2024Article
- GAS6 as a potential target to alleviate neuroinflammation during Japanese encephalitis in mouse models.Journal of neuroinflammation · 2024Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 2 countries.
Jian ChenScientific Research Center, Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, China.
Yi-Feng YangShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.
Yu YangScientific Research Center, Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, China.
Peng ZouScientific Research Center, Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, China.
Jun ChenDepartment of Ecology and Genetics, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden.
Yongquan HeScientific Research Center, Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, China.
Sai-Lan ShuiShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.
Yan-Ru CuiShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.
Ru BaiScientific Research Center, Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, China.
Ya-Jun LiangShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.
Yunwen HuScientific Research Center, Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, China.
Biao JiangShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.
Lu LuScientific Research Center, Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, China.
Xiaoyan ZhangScientific Research Center, Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, China. zhangxiaoyan@shaphc.org.cn.ORCID http://orcid.org/0000-0002-3193-1401
Jia LiuShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China. liujia@shanghaitech.edu.cn.ORCID http://orcid.org/0000-0001-9787-465X
Jianqing XuScientific Research Center, Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai, China. xujianqing@shaphc.org.cn.ORCID http://orcid.org/0000-0003-0896-9273
Fudan University · CNShanghaiTech University · CNShanghai Medical College of Fudan University · CNUppsala University · SE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zika virus (ZIKV) is associated with neonatal microcephaly and Guillain-Barré syndrome
Indexed as
Signal TransductionAstrocytesAxl Receptor Tyrosine KinaseCell LineCells, CulturedGene Expression RegulationGene Knockout TechniquesHumansInterferon Type IProto-Oncogene ProteinsReceptor, Interferon alpha-betaReceptor Protein-Tyrosine KinasesSTAT1 Transcription FactorSuppressor of Cytokine Signaling 1 ProteinZika VirusAxl Receptor Tyrosine KinaseIFNAR1 protein, humanInterferon Type IProto-Oncogene ProteinsReceptor, Interferon alpha-betaReceptor Protein-Tyrosine KinasesSOCS1 protein, humanSTAT1 protein, humanSTAT1 Transcription FactorSuppressor of Cytokine Signaling 1 Protein
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.