ArticleJournal of perinatology : official journal of the California Perinatal Association2018
The impact of altitude on screening for critical congenital heart disease.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Philippine Clinical Practice Guidelines for Periodic Health Examination: Screening for Congenital and Developmental Disorders.Acta medica Philippina · 2026Article
- A new algorithm DEtectS critical Congenital Heart Disease at different altitudes: ANDES-CHD study.Journal of perinatology : official journal of the California Perinatal Association · 2024Observational
- Trajectories of oxygen saturation within 6-72 hours after birth in neonates at moderate altitude: a prospective longitudinal cohort study.World journal of pediatrics : WJP · 2023Article
- Critical congenital heart disease detection in the ANDES: Challenges and opportunities.International journal of cardiology. Congenital heart disease · 2022Review
- Lower pass threshold (≥93%) for critical congenital heart disease screening at high altitude prevents repeat screening and reduces false positives.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- [Neonatal screening for critical congenital heart diseases in Peru: an urgent call].Archivos peruanos de cardiologia y cirugia cardiovascularReview
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe objectives were to determine the frequency with which pulse oximetry identifies critical congenital heart defects in asymptomatic full-term and late preterm newborns using the AAP expert panel algorithm in a variety of different hospital settings and to evaluate the impact of altitude on the rate of positive screens.
methodsWe conducted a prospective clinical study of implementation of a newborn pulse oximetry screening for congenital heart disease in 34 independent hospitals. Infants were eligible for enrollment if their gestational age was 35-44 weeks.
resultsOf the 34 sites which enrolled infants into our study, 24 were located at or below 2000 feet; 5 were located between 4700 and 6000 feet and 5 were located above 6000 feet in altitude. We screened 6109 infants; 65 (1.1%) had a positive screen. There were no differences in median gestational age, birth weight, mode of delivery or race/ethnicity for infants with a positive screen compared to infants with a negative screen. Infants with positive screens were more often male and more often born at sites located at high altitudes. The frequency of a positive screen increased from 0.2% for infants born at sites at or less than 2000 feet to 6% for sites located above 6000 feet. We stopped enrollment at the site located at 8163 feet after enrolling 65 infants because 23 (35%) were positive.
conclusionsScreening infants for critical cardiac defects at altitude is complicated by the increased false positive screens.
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Registered trials
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