ArticleScientific reports2018
A new method using Raman spectroscopy for in vivo targeted brain cancer tissue biopsy.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 1 synthesis or guideline pooled it, 200 citations in OpenAlex.
- Pooled it
- High-sensitivity Raman spectroscopy for prostate cancer detection and tissue extraction guidance.Biomedical optics express · 2026Article
- Spatially multiplexed random-access Raman probe for in vivo tissue measurements.Biomedical optics express · 2026Article
- Effect of fabrication error on the sensitivity of a one-dimensional photonic crystal sensor for cancer detection.Scientific reports · 2026Article
- Intraoperative Spectroscopic and Mass Spectrometric Assessment of Glioma Margins: A Systematic Review and Meta-Analysis.Cancers · 2026Review
- Machine-Learning-Enabled Raman Spectroscopy Refines Indocyanine Green Fluorescence Boundaries for Precise Glioblastoma Margin Delineation.Research (Washington, D.C.) · 2026Article
- Non-invasive Imaging Techniques: From Histology to In-vivo Imaging.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Pioneer of Biomedical Optics: Brian C. Wilson.Journal of biomedical optics · 2025Article
- Alternative Methodology for Cortisol Evaluation Before and After Sheep Shearing Using Raman Spectroscopy: A Feasibility Study.Animals : an open access journal from MDPI · 2025Article
- Challenges and opportunities for new intraoperative optical techniques in the surgical treatment of pituitary adenomas: a review.Journal of biomedical optics · 2025Review
- Towards Optical Biopsy in Glioma Surgery.International journal of molecular sciences · 2025Review
- Vibrational fiber photometry: label-free and reporter-free minimally invasive Raman spectroscopy deep in the mouse brain.Nature methods · 2025Article
- Review
- Single-cell Raman spectroscopy detects pediatric focal cortical dysplasia.Biophotonics discovery · 2025Article
- Current Applications of Raman Spectroscopy in Intraoperative Neurosurgery.Biomedicines · 2024Review
- Artifacts and Anomalies in Raman Spectroscopy: A Review on Origins and Correction Procedures.Molecules (Basel, Switzerland) · 2024Review
- Article
- Accurate and rapid molecular subgrouping of high-grade glioma via deep learning-assisted label-free fiber-optic Raman spectroscopy.PNAS nexus · 2024Article
- Label-free optical imaging for brain cancer assessment.Trends in cancer · 2024Review
- Robot-assisted biopsy sampling for online Raman spectroscopy cancer confirmation in the operating room.International journal of computer assisted radiology and surgery · 2024Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
Abstract
Modern cancer diagnosis requires histological, molecular, and genomic tumor analyses. Tumor sampling is often achieved using a targeted needle biopsy approach. Targeting errors and cancer heterogeneity causing inaccurate sampling are important limitations of this blind technique leading to non-diagnostic or poor quality samples, and the need for repeated biopsies pose elevated patient risk. An optical technology that can analyze the molecular nature of the tissue prior to harvesting could improve cancer targeting and mitigate patient risk. Here we report on the design, development, and validation of an in situ intraoperative, label-free, cancer detection system based on high wavenumber Raman spectroscopy. This optical detection device was engineered into a commercially available biopsy system allowing tumor analysis prior to tissue harvesting without disrupting workflow. Using a dual validation approach we show that high wavenumber Raman spectroscopy can detect human dense cancer with >60% cancer cells in situ during surgery with a sensitivity and specificity of 80% and 90%, respectively. We also demonstrate for the first time the use of this system in a swine brain biopsy model. These studies set the stage for the clinical translation of this optical molecular imaging method for high yield and safe targeted biopsy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.