ArticleNature neuroscience2018
Insular cortex mediates approach and avoidance responses to social affective stimuli.
Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers, 1 of them a synthesis that pooled it.
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Who cites it
145 citing papers in PubMed, 1 synthesis or guideline pooled it, 264 citations in OpenAlex.
- Social contagion of pain and fear results in opposite social behaviors in rodents: meta- analysis of experimental studies.Frontiers in behavioral neuroscience · 2024Pooled it
- Hypothalamic-amygdala gating of caregiving-like prosocial behavior in mice.The Journal of clinical investigation · 2026Article
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- Neurodegenerative-related gene rescue in anterior insula after early life maltreatment restores adult social interaction in male mice.Molecular psychiatry · 2026Article
- Strain-Dependent Network Activity Differences Underlie Social Decision-Making in Male Mice.eNeuro · 2026Article
- Oxytocin selectively biases sensory-prefrontal communication through network-level suppression and theta coupling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Spatial lipidomic and neuron-specific transcriptomic signatures in the nucleus accumbens reveal phospholipid dyshomeostasis in depression-related maladaptations.Translational psychiatry · 2026Article
- Oxytocin agonist TGOT differentially modulates synaptic plasticity and intrinsic excitability in a sex-specific manner in the juvenile rat hippocampus.Communications biology · 2026Article
- Neural correlates of social cognition in stroke and traumatic brain injury: A systematic review.Cognitive, affective & behavioral neuroscience · 2026Review
- Ultra-wide-field, deep, adaptive two-photon microscopy for multi-scale neuronal imaging.Light, science & applications · 2026Article
- Divergent Effects of Peripheral vs. Central Oxytocin Administration on Observational Fear Behavior in Male and Female Mice.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Oxytocin modulation of the insular cortex: implications for social cognition and neurodevelopmental disorders.Frontiers in neural circuits · 2026Review
- Oxytocinergic Signaling in Zebrafish: Translational Perspectives for Autism Spectrum Disorder.Journal of neurochemistry · 2026Review
- Multi-region social-emotional network underlying the effects of spine pinching therapy on empathy-like behavior in a rat model of autism spectrum disorder.Frontiers in neuroscience · 2026Article
- Interoception as a central mechanism in Whole Person Health.PLoS biology · 2025Article
- Insular input to the prelimbic cortex underlies social affective behavior in rats.bioRxiv : the preprint server for biology · 2025Article
- Subjective cognitive decline in major depressive patients is associated with altered entropy and connectivity changes of temporal and insular region.Translational psychiatry · 2025Article
- Merkel cell stimulation in fear and sensory signaling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Article
- Modulation of social valence by insular cortex activity during acute social isolation in mice.Molecular brain · 2025Article
85 more citing papers are in PubMed but not listed here.
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Social animals detect the affective states of conspecifics and utilize this information to orchestrate social interactions. In a social affective preference text in which experimental adult male rats could interact with either naive or stressed conspecifics, the experimental rats either approached or avoided the stressed conspecific, depending upon the age of the conspecific. Specifically, experimental rats approached stressed juveniles but avoided stressed adults. Inhibition of insular cortex, which is implicated in social cognition, and blockade of insular oxytocin receptors disrupted the social affective behaviors. Oxytocin application increased intrinsic excitability and synaptic efficacy in acute insular cortex slices, and insular oxytocin administration recapitulated the behaviors observed toward stressed conspecifics. Network analysis of c-Fos immunoreactivity in 29 regions identified functional connectivity between insular cortex, prefrontal cortex, amygdala and the social decision-making network. These results implicate insular cortex as a key component in the circuit underlying age-dependent social responses to stressed conspecifics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.