ArticleScientific reports2018
DNA structure at the plasmid origin-of-transfer indicates its potential transfer range.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Expanding the diversity of origin of transfer-containing sequences in mobilizable plasmids.Nature microbiology · 2024Article
- Evolution of the TnMicrobiology spectrum · 2024Article
- Multiple relaxases contribute to the horizontal transfer of the virulence plasmids from the tumorigenic bacteriumFrontiers in microbiology · 2022Article
- Insights into the ancestry evolution of theNAR genomics and bioinformatics · 2021Article
- Swine growth promotion with antibiotics or alternatives can increase antibiotic resistance gene mobility potential.Scientific reports · 2021Article
- Learning the Regulatory Code of Gene Expression.Frontiers in molecular biosciences · 2021Review
- Performance of Regression Models as a Function of Experiment Noise.Bioinformatics and biology insights · 2021Article
- Multiple plasmid origin-of-transfer regions might aid the spread of antimicrobial resistance to human pathogens.MicrobiologyOpen · 2020Article
- Deep learning suggests that gene expression is encoded in all parts of a co-evolving interacting gene regulatory structure.Nature communications · 2020Article
- Understanding Horizontal Gene Transfer network in human gut microbiota.Gut pathogens · 2020Article
- Determining the Virulence Properties ofMicroorganisms · 2019Article
- DNA processing by the MOBH family relaxase TraI encoded within the gonococcal genetic island.Nucleic acids research · 2019Article
- Evidence of Illegitimate Recombination Between TwoFrontiers in microbiology · 2018Article
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2 authors.
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Abstract
Horizontal gene transfer via plasmid conjugation enables antimicrobial resistance (AMR) to spread among bacteria and is a major health concern. The range of potential transfer hosts of a particular conjugative plasmid is characterised by its mobility (MOB) group, which is currently determined based on the amino acid sequence of the plasmid-encoded relaxase. To facilitate prediction of plasmid MOB groups, we have developed a bioinformatic procedure based on analysis of the origin-of-transfer (oriT), a merely 230 bp long non-coding plasmid DNA region that is the enzymatic substrate for the relaxase. By computationally interpreting conformational and physicochemical properties of the oriT region, which facilitate relaxase-oriT recognition and initiation of nicking, MOB groups can be resolved with over 99% accuracy. We have shown that oriT structural properties are highly conserved and can be used to discriminate among MOB groups more efficiently than the oriT nucleotide sequence. The procedure for prediction of MOB groups and potential transfer range of plasmids was implemented using published data and is available at http://dnatools.eu/MOB/plasmid.html .
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