ArticleScientific reports2018
The antidepressant fluoxetine acts on energy balance and leptin sensitivity via BDNF.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Effects of 6-months of SSRI use on DNA-methylation and gene expression in blood.Brain, behavior, and immunity · 2026Trial
- Parallel Pathways, Divergent Outcomes: Adipose Tissue-Neural Crosstalk in Depression and Obesity.Journal of clinical medicine · 2025Review
- A New Strategy for Obesity Treatment: Revealing the Frontiers of Anti-obesity Medications.Current molecular medicine · 2025Review
- Reprogramming energy homeostasis in children with overweight through cognitive training and social interaction. A study protocol to estimate leptin sensitivity.Frontiers in endocrinology · 2025Article
- The association between the fluoxetine use and the occurrence of coronary heart disease: a nationwide retrospective cohort study.BMC cardiovascular disorders · 2024Article
- Molecular and functional mapping of the neuroendocrine hypothalamus: a new era begins.Journal of endocrinological investigation · 2024Review
- Mechanisms Involved in the Link between Depression, Antidepressant Treatment, and Associated Weight Change.International journal of molecular sciences · 2024Review
- Endothelial nitric oxide synthase (eNOS) S1176 phosphorylation status governs atherosclerotic lesion formation.Frontiers in cardiovascular medicine · 2023Article
- The Plasma Levels of 3-Hydroxybutyrate, Dityrosine, and Other Markers of Oxidative Stress and Energy Metabolism in Major Depressive Disorder.Diagnostics (Basel, Switzerland) · 2022Article
- Change of hypothalamic adult neurogenesis in mice by chronic treatment of fluoxetine.BMC research notes · 2022Article
- Leptin, the brain and energy homeostasis: From an apparently simple to a highly complex neuronal system.Reviews in endocrine & metabolic disorders · 2022Review
- Azepine-Indole Alkaloids FromFrontiers in neuroscience · 2022Article
- The role of leptin in indirectly mediating "somatic anxiety" symptoms in major depressive disorder.Frontiers in psychiatry · 2022Article
- How Antidepressant Drugs Affect the Antielectroshock Action of Antiseizure Drugs in Mice: A Critical Review.International journal of molecular sciences · 2021Review
- TPH2 in the Dorsal Raphe Nuclei Regulates Energy Balance in a Sex-Dependent Manner.Endocrinology · 2021Article
- Evaluating Prevalence and Patterns of Prescribing Medications for Depression for Patients With Obesity Using Large Primary Care Data (Canadian Primary Care Sentinel Surveillance Network).Frontiers in nutrition · 2020Article
- Characterization of the Therapeutic Profile of Albiflorin for the Metabolic Syndrome.Frontiers in pharmacology · 2019Article
- Editorial: Metabolic Mediators and Synapses: Linking Body Periphery to Neural Plasticity.Frontiers in cellular neuroscience · 2019Article
- Fluoxetine Modulates the Activity of Hypothalamic POMC Neurons via mTOR Signaling.Molecular neurobiology · 2018Article
- Fluoxetine exposure in adolescent and adult female mice decreases cocaine and sucrose preference later in life.Journal of psychopharmacology (Oxford, England) · 2018Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptin and Brain Derived Neurotrophic Factor (BDNF) pathways are critical players in body weight homeostasis. Noninvasive treatments like environmental stimulation are able to increase response to leptin and induce BDNF expression in the brain. Emerging evidences point to the antidepressant selective serotonin reuptake inhibitor Fluoxetine (FLX) as a drug with effects similar to environmental stimulation. FLX is known to impact on body weight, with mechanisms yet to be elucidated. We herein asked whether FLX affects energy balance, the leptin system and BDNF function. Adult lean male mice chronically treated with FLX showed reduced weight gain, higher energy expenditure, increased sensitivity to acute leptin, increased hypothalamic BDNF expression, associated to changes in white adipose tissue expression typical of "brownization". In the Ntrk2
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.