Evidence map›Paper›PMID 29379092›Full record

ArticleScientific reports2018

Malignancy dominated with rheumatic manifestations: A retrospective single-center analysis.

Jian Wen, Han Ouyang, Ru Yang, Lin Bo, Yi Zhang, Mei Tang, Zhichun Liu

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Cardiac Angiosarcoma: A Diagnostic and Therapeutic Challenge.The Kaohsiung journal of medical sciences · 2025
    Article
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  6. Article
  7. Article
  8. Article
  9. A 40-Year-Old Woman with Asymmetric Arthritis and Skin Lesions.Mediterranean journal of rheumatology · 2019
    Article
  10. Article
  11. Article
  12. Article
  13. Sensing acidosis: nociception or sngception?Journal of biomedical science · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jian WenDepartment of Rheumatology and Immunology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Han OuyangDepartment of Nephrology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Ru YangDepartment of Rheumatology and Immunology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Lin BoDepartment of Rheumatology and Immunology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Yi ZhangDepartment of Rheumatology and Immunology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Mei TangDepartment of Rheumatology and Immunology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Zhichun LiuDepartment of Rheumatology and Immunology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. lzchun5190@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paraneoplastic rheumatic syndromes comprise a heterogeneous group of disorders characterized by typical rheumatic manifestations but without direct invasion by the tumor or metastases. The clinical features and malignancy-associated risk factors of 21 patients with paraneoplastic rheumatic syndromes, including 11 men and 10 women with a mean age of 56.3 ± 13.1 years, were characterized by a retrospective review. All patients were diagnosed with malignancy within 2 years of rheumatism diagnosis. Patients suffering from solid malignancies accounted for the majority (62%); hematological malignancies were observed in the remainder. Arthritis (48%), lymph node enlargement (38%), skin rash (38%), weight loss (29%), fever/chills (24%), fatigue (24%), muscle soreness (24%) and smoking history (29%) were common findings. Except for 8 patients (38%) who tested positive for anti-nuclear antibody (ANA) and 9 positive for rheumatoid factor (RF), all patients tested negative for anti-extractable nuclear antigen (ENA) antibodies. Rheumatic disorders with a typical clinical presentation in older patients and nonspecific systemic features should alert clinicians to search for an occult malignancy. Patients with rheumatic disease must be closely followed to screen for malignancies, particularly within 2 years of rheumatism diagnosis.

Indexed as

Antibodies, AntinuclearFemaleHumansMaleMiddle AgedNeoplasms, Unknown PrimaryParaneoplastic SyndromesRetrospective StudiesRheumatic DiseasesAntibodies, Antinuclearanti-extractable nuclear antigen antibodies

Identifiers

PMID29379092
PMCPMC5789019

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.