ArticleNature communications2018
Control of primary metabolism by a virulence regulatory network promotes robustness in a plant pathogen.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A genome-scale metabolic model of a pathosystem sheds light on bacterial wilt.Plant physiology · 2026Article
- Article
- New insights in metabolism modelling to decipher plant-microbe interactions.The New phytologist · 2025Review
- Applications of genome-scale metabolic models to investigate microbial metabolic adaptations in response to genetic or environmental perturbations.Briefings in bioinformatics · 2023Review
- Virulence and Metabolism Crosstalk: Impaired Activity of the Type Three Secretion System (T3SS) in aInternational journal of molecular sciences · 2023Article
- NorA, HmpX, and NorB Cooperate to Reduce NO Toxicity during Denitrification and Plant Pathogenesis inMicrobiology spectrum · 2022Article
- Trophic preferences of the pathogen Ralstonia solanacearum and consequences on its growth in xylem sap.MicrobiologyOpen · 2022Article
- Insights intoBiology · 2021Article
- The mRNA derived MalH sRNA contributes to alternative carbon source utilization by tuning maltoporin expression in E. coli.RNA biology · 2021Article
- Convergent Rewiring of the Virulence Regulatory Network Promotes Adaptation of Ralstonia solanacearum on Resistant Tomato.Molecular biology and evolution · 2021Article
- Genome-wide association of rice response to blast fungus identifies loci for robust resistance under high nitrogen.BMC plant biology · 2021Article
- Uncovering the Role of Metabolism in Oomycete-Host Interactions Using Genome-Scale Metabolic Models.Frontiers in microbiology · 2021Review
- High abundance of Ralstonia solanacearum changed tomato rhizosphere microbiome and metabolome.BMC plant biology · 2020Article
- Genome-Scale Investigation of the Metabolic Determinants Generating Bacterial Fastidious Growth.mSystems · 2020Article
- Article
- QseC Inhibition as a Novel Antivirulence Strategy for the Prevention of Acute Hepatopancreatic Necrosis Disease (AHPND)-CausingFrontiers in cellular and infection microbiology · 2020Article
- Phage combination therapies for bacterial wilt disease in tomato.Nature biotechnology · 2019Article
- Metabolic Model of themBio · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Robustness is a key system-level property of living organisms to maintain their functions while tolerating perturbations. We investigate here how a regulatory network controlling multiple virulence factors impacts phenotypic robustness of a bacterial plant pathogen. We reconstruct a cell-scale model of Ralstonia solanacearum connecting a genome-scale metabolic network, a virulence macromolecule network, and a virulence regulatory network, which includes 63 regulatory components. We develop in silico methods to quantify phenotypic robustness under a broad set of conditions in high-throughput simulation analyses. This approach reveals that the virulence regulatory network exerts a control of the primary metabolism to promote robustness upon infection. The virulence regulatory network plugs into the primary metabolism mainly through the control of genes likely acquired via horizontal gene transfer, which results in a functional overlay with ancestral genes. These results support the view that robustness may be a selected trait that promotes pathogenic fitness upon infection.
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