Evidence map›Paper›PMID 29379071›Full record

ArticleScientific reports2018

L. plantarum WCFS1 enhances Treg frequencies by activating DCs even in absence of sampling of bacteria in the Peyer Patches.

Miriam Bermudez-Brito, Theo Borghuis, Catherine Daniel, Bruno Pot, Bart J de Haan, Marijke M Faas, Paul de Vos

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
  2. Nutrients · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Heat-killedFrontiers in microbiology · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. Frontiers in microbiology · 2021
    Review
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Miriam Bermudez-BritoTop Institute Food and Nutrition, Wageningen, The Netherlands. m.bermudez.brito@gmail.com.
Theo BorghuisDept. Pathology and Medical Biology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.
Catherine DanielCNRS, INSERM U1019, CHU Lille, Institut Pasteur de Lille, UMR8204 - CIIL - Center for Infection and Immunity of Lille, University of Lille, Lille, France.
Bruno PotResearch Group of Industrial Microbiology and Food Biotechnology, Faculty of Sciences and Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.
Bart J de HaanDept. Pathology and Medical Biology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.
Marijke M FaasDept. Pathology and Medical Biology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.
Paul de VosTop Institute Food and Nutrition, Wageningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Probiotics such as L. plantarum WCFS1 can modulate immune responses in healthy subjects but how this occurs is still largely unknown. Immune-sampling in the Peyer Patches has been suggested to be one of the mechanisms. Here we studied the systemic and intestinal immune effects in combination with a trafficking study through the intestine of a well-established immunomodulating probiotic, i.e. L. plantarum WCFS1. We demonstrate that not more than 2-3 bacteria were sampled and in many animals not any bacterium could be found in the PP. Despite this, L. plantarum was associated with a strong increase in infiltration of regulatory CD103

Indexed as

AnimalsCytokinesDendritic CellsImmunomodulationIntestinesLactiplantibacillus plantarumMaleMiceMice, Inbred BALB CPeyer's PatchesProbioticsSpleenT-Lymphocytes, Helper-InducerT-Lymphocytes, RegulatoryCytokines

Identifiers

PMID29379071
PMCPMC5788989

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.