ArticleScientific reports2018
The functional and structural alterations of the striatum in chronic spontaneous urticaria.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Clinical efficacy and safety of acupuncture in the treatment for chronic spontaneous urticaria: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Chronic Spontaneous Urticaria and Psychiatric Symptoms: The Blood-Brain Barrier Hypothesis.Experimental dermatology · 2026Review
- MRI-based neuroimaging alterations in immune-related skin diseases: a comprehensive review.Archives of dermatological research · 2025Review
- Voxel-based morphometry reveals immune-metabolic dysregulation driving adaptive cortical gray matter remodeling in patients with esophageal cancer.Frontiers in oncology · 2025Article
- Gray matter volume microstructural alterations in chronic post-burn pruritus: a voxel-based morphometry analysis using 3D T1-weighted imaging.Frontiers in neuroscience · 2025Article
- Efficacy and Mechanism of Acupoint Catgut Embedding in the Treatment of Chronic Spontaneous Urticaria: Protocol for a Randomized Double-Blind Placebo-Controlled Trial.JMIR research protocols · 2024Article
- Itch: from the skin to the brain - peripheral and central neural sensitization in chronic itch.Frontiers in molecular neuroscience · 2023Review
- Relationship Between Sensitivity to Disgust and Irritable Bowel Syndrome: A Study on Healthy Individuals.Clinical neuropsychiatry · 2022Article
- Structural and Functional Asymmetry in Precentral and Postcentral Gyrus in Patients With Unilateral Chronic Shoulder Pain.Frontiers in neurology · 2022Article
- Functional connectivity impairment of thalamus-cerebellum-scratching neural circuits in pruritus of chronic spontaneous urticaria.Frontiers in neuroscience · 2022Article
- Itch Matrixes.Frontiers in medicine · 2021Article
- Neural Advantages of Older Musicians Involve the Cerebellum: Implications for Healthy Aging Through Lifelong Musical Instrument Training.Frontiers in human neuroscience · 2021Article
- Research on Characteristic of Chronic Spontaneous Urticaria Based on Multiscale Entropy.Computational and mathematical methods in medicine · 2021Article
- Is chronic urticaria more than skin deep?Clinical and translational allergy · 2019Review
- The Dysfunction of the Cerebellum and Its Cerebellum-Reward-Sensorimotor Loops in Chronic Spontaneous Urticaria.Cerebellum (London, England) · 2018Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
The brain has long been known to be the regulation center of itch, but the neuropathology of chronic itch, such as chronic spontaneous urticaria (CSU), remains unclear. Thus, we aimed to explore the brain areas involved in the pathophysiology of CSU in hopes that our results may provide valuable insights into the treatment of chronic itch conditions. 40 CSU patients and 40 healthy controls (HCs) were recruited. Urticaria activity scores 7 (UAS7) were collected to evaluate patient's clinical symptoms. Amplitude of low frequency fluctuations (ALFF), voxel-based morphometry (VBM), and seed-based resting-state functional connectivity (rs-FC) analysis were used to assess brain activity and related plasticity. Compared with HCs, CSU patients exhibited 1) higher ALFF values in the right ventral striatum / putamen, which were positively associated with clinical symptoms as measured by UAS7; 2) gray matter volume (GMV) increase in the right ventral striatum and putamen; and 3) decreased rs-FC between the right ventral striatum and the right occipital cortex and between the right putamen and the left precentral gyrus. Using multiple-modality brain imaging tools, we demonstrated the dysfunction of the striatum in CSU. Our results may provide valuable insights into the neuropathology and development of chronic itch.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.