ArticleScientific reports2018
A Low-Cost Palmtop High-Speed Capillary Electrophoresis Bioanalyzer with Laser Induced Fluorescence Detection.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The Design of a Bioinspired Integrated Total Habitability Instrument for Planetary Exploration: A Review of Potential Sensing Technologies.Biomimetics (Basel, Switzerland) · 2025Review
- A Highly Portable Smartphone-Based Capillary Electrophoresis with Capacitively Coupled Contactless Conductivity Detection.Sensors (Basel, Switzerland) · 2025Article
- Development of a Low-Cost and Easy-Assembly Capillary Electrophoresis System for Separation of DNA.Bioengineering (Basel, Switzerland) · 2025Article
- Green analytical chemistry: integrating sustainability into undergraduate education.Analytical and bioanalytical chemistry · 2025Article
- Compact Laser-Induced Fluorescence Detector with Adjustable Laser Focal Spot for Multiple Purposes.Sensors (Basel, Switzerland) · 2024Article
- Low-cost molecular methods to characterise gastrointestinal nematode co-infections of goats in Africa.Parasites & vectors · 2023Article
- Lab at home: a promising prospect for on-site chemical and biological analysis.Analytical and bioanalytical chemistry · 2023Article
- A handheld-type total integrated capillary electrophoresis system for SARS-CoV-2 diagnostics: Power, fluorescence detection, and data analysis by smartphone.Biosensors & bioelectronics · 2022Article
- Review
- Low-cost and open-source strategies for chemical separations.Journal of chromatography. A · 2021Review
- A Two-Dimensional Affinity Capture and Separation Mini-Platform for the Isolation, Enrichment, and Quantification of Biomarkers and Its Potential Use for Liquid Biopsy.Biomedicines · 2020Review
- Microfluidic approaches for the analysis of protein-protein interactions in solution.Biophysical reviews · 2020Review
- Article
- Automatic Dissolution Testing with High-Temporal Resolution for Both Immediate-Release and Fixed-Combination Drug Tablets.Scientific reports · 2019Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work, we developed a miniaturized palmtop high-speed capillary electrophoresis (CE) system integrating whole modules, including picoliter-scale sample injection, short capillary-based fast CE, high-voltage power supply, orthogonal laser induced fluorescence (LIF) detection, battery, system control, on-line data acquisition, processing, storage, and display modules. A strategy of minimalist miniaturization combining minimal system design and low-cost system construction was adopted to achieve the instrument miniaturization with extremely low cost, which is differing from the current microfabrication strategy used in most reported miniaturized CE systems. With such a strategy, the total size of the bioanalyzer was minimized to 90 × 75 × 77 mm (length × width × height) and the instrument cost was reduced to ca. $500, which demonstrated the smallest and lowest-cost CE instrument with LIF detection in so far reported systems. The present bioanalyzer also exhibited comparable analytical performances to previously-reported high-speed CE systems. A limit of detection of 1.02 nM sodium fluorescein was obtained. Fast separations were achieved for multiple types of samples as amino acids, amino acid enantiomers, DNA fragments, and proteins with high efficiency. We applied this instrument in colorectal cancer diagnosis for detecting KRAS mutation status by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
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