Evidence map›Paper›PMID 29379040›Full record

ArticleScientific reports2018

MRI of the cervical spinal cord predicts respiratory dysfunction in ALS.

G Grolez, M Kyheng, R Lopes, C Moreau, K Timmerman, F Auger, G Kuchcinski, A Duhamel, P Jissendi-Tchofo, P Besson and 9 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02360891 (Study of Predictive Factors of Progression of Motor Neurone Disease Prognosis and Endophenotype Biomarkers French Database Set up), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02360891 completednot on this map

Study of Predictive Factors of Progression of Motor Neurone Disease Prognosis and Endophenotype Biomarkers French Database Set up

Typeobservational_patient_registrySponsorUniversity Hospital, LilleRan2015 to 2025Enrolled500ConditionsAmyotrophic Lateral Sclerosis, Motor Neuron DiseaseArmsbiomarkers (composite analysis)
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Potential Roles of Neuroimaging in Motor Neuron Disease.Current neurology and neuroscience reports · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Combined brain and spinal FDG PET allows differentiation between ALS and ALS mimics.European journal of nuclear medicine and molecular imaging · 2020
    Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 2 countries.

G GrolezService de Neurologie, Université de Lille, CHU de Lille, INSERM UMRS_1171, LICEND COEN Center, Lille, France.
M KyhengDépartement de Biostastistiques, Université de Lille, CHU de Lille, Lille, France.
R LopesService de Neuroradiologie, Université de Lille, CHU de Lille, INSERM UMRS_1171, LICEND COEN Center Lille, Lille, France.
C MoreauService de Neurologie, Université de Lille, CHU de Lille, INSERM UMRS_1171, LICEND COEN Center, Lille, France.
K TimmermanService de Pharmacologie, Médicale Université de Lille, CHU de Lille, INSERM UMRS_1171, LICEND COEN Center Lille, Lille, France.
F AugerPlateau d'imagerie préclinique, Université de Lille, CHU de Lille, Lille, France.
G KuchcinskiService de Neuroradiologie, Université de Lille, CHU de Lille, INSERM UMRS_1171, LICEND COEN Center Lille, Lille, France.
A DuhamelDépartement de Biostastistiques, Université de Lille, CHU de Lille, Lille, France.
P Jissendi-TchofoService de Neuroradiologie, Université de Lille, CHU de Lille, INSERM UMRS_1171, LICEND COEN Center Lille, Lille, France.
P BessonService de Neuroradiologie, Université de Lille, CHU de Lille, INSERM UMRS_1171, LICEND COEN Center Lille, Lille, France.
C LalouxService de Pharmacologie, Médicale Université de Lille, CHU de Lille, INSERM UMRS_1171, LICEND COEN Center Lille, Lille, France.
M PetraultService de Pharmacologie, Médicale Université de Lille, CHU de Lille, INSERM UMRS_1171, LICEND COEN Center Lille, Lille, France.
J C DevedjianService de Pharmacologie, Médicale Université de Lille, CHU de Lille, INSERM UMRS_1171, LICEND COEN Center Lille, Lille, France.
Thierry PérezService de Pneumologie, Université de Lille, CHU de Lille, Lille, France.
Pierre François PradatLaboratoire d'Imagerie Biomédicale, CNRS, INSERM, Sorbonne Universités, UPMC Univ Paris 06, Paris, France.
L DefebvreService de Neurologie, Université de Lille, CHU de Lille, INSERM UMRS_1171, LICEND COEN Center, Lille, France.
R BordetService de Pharmacologie, Médicale Université de Lille, CHU de Lille, INSERM UMRS_1171, LICEND COEN Center Lille, Lille, France.
V Danel-BrunaudService de Neurologie, Université de Lille, CHU de Lille, INSERM UMRS_1171, LICEND COEN Center, Lille, France.
D DevosService de Neurologie, Université de Lille, CHU de Lille, INSERM UMRS_1171, LICEND COEN Center, Lille, France. david.devos@chru-lille.fr.ORCID http://orcid.org/0000-0002-2417-799X
Inserm · FRUniversité de Lille · FRCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For patients with amyotrophic lateral sclerosis (ALS), the primary therapeutic goal is to minimize morbidity. Non-invasive ventilation improves survival. We aim to assess whether Magnetic Resonance Imaging (MRI) of the cervical spinal cord predicts the progression of respiratory disorders in ALS. Brain and spinal MRI was repeatedly performed in the SOD1

Indexed as

Amyotrophic Lateral SclerosisAnimalsCervical CordDisease Models, AnimalDisease ProgressionHumansMagnetic Resonance ImagingMedulla OblongataMiceMotor CortexMotor NeuronsRespiratory Tract DiseasesSpinal CordSuperoxide Dismutase-1White MatterSuperoxide Dismutase-1

Identifiers

PMID29379040
PMCPMC5789036
OpenAlexW2805500116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.